A Commentary on 'Common SNPs Explain a Large Proportion of the Heritability for Human Height' by Yang et al. (2010)

Visscher, Peter M., Yang, Jian and Goddard, Michael E. (2010) A Commentary on 'Common SNPs Explain a Large Proportion of the Heritability for Human Height' by Yang et al. (2010). Twin Research and Human Genetics, 13 6: 517-524. doi:10.1375/twin.13.6.517


Author Visscher, Peter M.
Yang, Jian
Goddard, Michael E.
Title A Commentary on 'Common SNPs Explain a Large Proportion of the Heritability for Human Height' by Yang et al. (2010)
Journal name Twin Research and Human Genetics   Check publisher's open access policy
ISSN 1832-4274
1839-2628
Publication date 2010-12
Year available 2010
Sub-type Editorial
DOI 10.1375/twin.13.6.517
Open Access Status
Volume 13
Issue 6
Start page 517
End page 524
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2010
Language eng
Formatted abstract
 Recently a paper authored by ourselves and a number of co-authors about the proportion of phenotypic variation in height that is explained by common SNPs was published in Nature Genetics (Yang et al., 2010). Common SNPs explain a large proportion of the heritability for human height (Yang et al.). During the refereeing process (the paper was rejected by two other journals before publication in Nature Genetics) and following the publication of Yang et al. (2010) it became clear to us that the methodology we applied, the interpretation of the results and the consequences of the findings on the genetic architecture of human height and that for other traits such as complex disease are not well understood or appreciated. Here we explain some of these issues in a style that is different from the primary publication, that is, in the form of a number of comments and questions and answers. We also report a number of additional results that show that the estimates of additive genetic variation are not driven by population structure.
Keyword Genomic Predictions
Linkage Disequilibrium
Heritability
Height
Genes
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Editorial
Collection: Queensland Brain Institute Publications
 
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