Influence of outliers on QTL mapping for complex traits

Hayat, Yousaf, Yang, Jian, Xu, Hai-ming and Zhu, Jun (2008) Influence of outliers on QTL mapping for complex traits. Journal of Zhejiang University-Science B, 9 12: 931-937. doi:10.1631/jzus.B0820045

Author Hayat, Yousaf
Yang, Jian
Xu, Hai-ming
Zhu, Jun
Title Influence of outliers on QTL mapping for complex traits
Journal name Journal of Zhejiang University-Science B   Check publisher's open access policy
ISSN 1673-1581
Publication date 2008-12
Year available 2008
Sub-type Article (original research)
DOI 10.1631/jzus.B0820045
Open Access Status
Volume 9
Issue 12
Start page 931
End page 937
Total pages 7
Place of publication Zhejiang, China
Publisher Zheijiang University Press
Language eng
Formatted abstract
A method was proposed for the detection of outliers and influential observations in the framework of a mixed linear model, prior to the quantitative trait locus (QTL) mapping analysis. We investigated the impact of outliers on QTL mapping for complex traits in a mouse BXD population, and observed that the dropping of outliers could provide the evidence of additional QTL and epistatic loci affecting the 1stBrain-OB and the 2ndBrain-OB in a cross of the abovementioned population. The results could also reveal a remarkable increase in estimating heritabilities of QTL in the absence of outliers. In addition, simulations were conducted to investigate the detection powers and false discovery rates (FDRs) of QTLs in the presence and absence of outliers. The results suggested that the presence of a small proportion of outliers could increase the FDR and hence decrease the detection power of QTLs. A drastic increase could be obtained in the estimates of standard errors for position, additive and additive×environment interaction effects of QTLs in the presence of outliers.
Keyword QTL mapping
Outliers and influential observations
Complex trait
Quantitative traits
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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