Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Bønnelykke, Klaus, Matheson, Melanie C., Pers, Tune H., Granell, Raquel, Strachan, David P., Alves, Alexessander Couto, Linneberg, Allan, Curtin, John A., Warrington, Nicole M., Standl, Marie, Kerkhof, Marjan, Jonsdottir, Ingileif, Bukvic, Blazenka K., Kaakinen, Marika, Sleimann, Patrick, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Schramm, Katharina, Baltic, Svetlana, Kreiner-Møller, Eskil, Simpson, Angela, St Pourcain, Beate, Coin, Lachlan, Hui, Jennie, Walters, Eugene H., Tiesler, Carla M. T., Duffy, David L., Jones, Graham, Ring, Susan M., McArdle, Wendy L., Price, Loren, Robertson, Colin F., Pekkanen, Juha, Tang, Clara S., Thiering, Elisabeth, Montgomery, Grant W., Hartikainen, Anna-Liisa, Dharmage, Shyamali C., Husemoen, Lise L., Herder, Christian, Kemp, John P., Elliot, Paul, James, Alan, Waldenberger, Melanie, Abramson, Michael J., Fairfax, Benjamin P., Knight, Julian C., Gupta, Ramneek, Thompson, Philip J., Holt, Patrick, Sly, Peter, Hirschhorn, Joel N., Blekic, Mario, Weidinger, Stephan, Hakonarsson, Hakon, Stefansson, Kari, Heinrich, Joachim, Postma, Dirkje S., Custovic, Adnan, Pennell, Craig E., Jarvelin, Marjo-Riitta, Koppelman, Gerard H., Timpson, Nicholas, Ferreira, Manuel A., Bisgaard, Hans, Henderson, A. John, Australian Asthma Genetics Consortium (AAGC), Danoy, Patrick, Henders, Anjali K., Jenkins, Mark, Martin, Nicholas G. and Brown, Matthew A. (2013) Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization. Nature Genetics, 45 8: 902-906. doi:10.1038/ng.2694


Author Bønnelykke, Klaus
Matheson, Melanie C.
Pers, Tune H.
Granell, Raquel
Strachan, David P.
Alves, Alexessander Couto
Linneberg, Allan
Curtin, John A.
Warrington, Nicole M.
Standl, Marie
Kerkhof, Marjan
Jonsdottir, Ingileif
Bukvic, Blazenka K.
Kaakinen, Marika
Sleimann, Patrick
Thorleifsson, Gudmar
Thorsteinsdottir, Unnur
Schramm, Katharina
Baltic, Svetlana
Kreiner-Møller, Eskil
Simpson, Angela
St Pourcain, Beate
Coin, Lachlan
Hui, Jennie
Walters, Eugene H.
Tiesler, Carla M. T.
Duffy, David L.
Jones, Graham
Ring, Susan M.
McArdle, Wendy L.
Price, Loren
Robertson, Colin F.
Pekkanen, Juha
Tang, Clara S.
Thiering, Elisabeth
Montgomery, Grant W.
Hartikainen, Anna-Liisa
Dharmage, Shyamali C.
Husemoen, Lise L.
Herder, Christian
Kemp, John P.
Elliot, Paul
James, Alan
Waldenberger, Melanie
Abramson, Michael J.
Fairfax, Benjamin P.
Knight, Julian C.
Gupta, Ramneek
Thompson, Philip J.
Holt, Patrick
Sly, Peter
Hirschhorn, Joel N.
Blekic, Mario
Weidinger, Stephan
Hakonarsson, Hakon
Stefansson, Kari
Heinrich, Joachim
Postma, Dirkje S.
Custovic, Adnan
Pennell, Craig E.
Jarvelin, Marjo-Riitta
Koppelman, Gerard H.
Timpson, Nicholas
Ferreira, Manuel A.
Bisgaard, Hans
Henderson, A. John
Australian Asthma Genetics Consortium (AAGC)
Danoy, Patrick
Henders, Anjali K.
Jenkins, Mark
Martin, Nicholas G.
Brown, Matthew A.
Total Author Count Override 67
Title Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-08
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2694
Open Access Status
Volume 45
Issue 8
Start page 902
End page 906
Total pages 5
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2014
Language eng
Formatted abstract
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
Keyword Susceptibility loci
Gene-expression
Crohns-disease
Risk loci
Asthma
Variants
Atopy
Mechanisms
Micrornas
Number
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 30 June 2013.

 
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