Intracellular trafficking and secretion of inflammatory cytokines

Stow, Jennifer L. and Murray, Rachael Z. (2013) Intracellular trafficking and secretion of inflammatory cytokines. Cytokine and Growth Factor Reviews, 24 3: 227-239. doi:10.1016/j.cytogfr.2013.04.001

Author Stow, Jennifer L.
Murray, Rachael Z.
Title Intracellular trafficking and secretion of inflammatory cytokines
Journal name Cytokine and Growth Factor Reviews   Check publisher's open access policy
ISSN 1359-6101
Publication date 2013-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cytogfr.2013.04.001
Volume 24
Issue 3
Start page 227
End page 239
Total pages 13
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Abstract The secretion of cytokines by immune cells plays a significant role in determining the course of an inflammatory response. The levels and timing of each cytokine released are critical for mounting an effective but confined response, whereas excessive or dysregulated inflammation contributes to many diseases. Cytokines are both culprits and targets for effective treatments in some diseases. The multiple points and mechanisms that have evolved for cellular control of cytokine secretion highlight the potency of these mediators and the fine tuning required to manage inflammation. Cytokine production in cells is regulated by cell signaling, and at mRNA and protein synthesis levels. Thereafter, the intracellular transport pathways and molecular trafficking machinery have intricate and essential roles in dictating the release and activity of cytokines. The trafficking machinery and secretory (exocytic) pathways are complex and highly regulated in many cells, involving specialized membranes, molecules and organelles that enable these cells to deliver cytokines to often-distinct areas of the cell surface, in a timely manner. This review provides an overview of secretory pathways – both conventional and unconventional – and key families of trafficking machinery. The prevailing knowledge about the trafficking and secretion of a number of individual cytokines is also summarized. In conclusion, we present emerging concepts about the functional plasticity of secretory pathways and their modulation for controlling cytokines and inflammation.
Keyword Cytokine secretion
Conventional secretion
Unconventional secretion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
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