pH-responsive star polymer nanoparticles: potential F-19 MRI contrast agents for tumour-selective imaging

Wang, Kewei, Peng, Hui, Thurecht, Kristofer J., Puttick, Simon and Whittaker, Andrew K. (2013) pH-responsive star polymer nanoparticles: potential F-19 MRI contrast agents for tumour-selective imaging. Polymer Chemistry, 4 16: 4480-4489. doi:10.1039/c3py00654a


Author Wang, Kewei
Peng, Hui
Thurecht, Kristofer J.
Puttick, Simon
Whittaker, Andrew K.
Title pH-responsive star polymer nanoparticles: potential F-19 MRI contrast agents for tumour-selective imaging
Formatted title
pH-responsive star polymer nanoparticles: potential 19F MRI contrast agents for tumour-selective imaging
Journal name Polymer Chemistry   Check publisher's open access policy
ISSN 1759-9954
1759-9962
Publication date 2013-08-21
Sub-type Article (original research)
DOI 10.1039/c3py00654a
Open Access Status Not Open Access
Volume 4
Issue 16
Start page 4480
End page 4489
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Collection year 2014
Language eng
Formatted abstract
Star polymers with a branched core and hydrophilic arms were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization as pH-responsive 19F magnetic resonance imaging (MRI) agents. The branched core consists of 2,2,2-trifluoroethyl acrylate (TFEA, providing 19F MRI signal) and 2-(dimethylamino)ethyl methacrylate (DMAEMA, offering pH-responsive properties). The arms are comprised of poly(poly(ethylene glycol) methyl ether methacrylate) (PPEGMA) brushes that form hydrophilic and biocompatible shells around the cores. The structure and composition of the star polymers were characterised in detail. Nanoparticles were fabricated by direct dissolution of the star polymers in aqueous solution. 19F nuclear magnetic resonance (19F NMR) revealed that the 19F signal intensity and spin–spin relaxation time (T2) were significantly dependent on the pH of polymer solution, while the 19F spin-lattice (T1) relaxation time remained constantly low at ~450 ms upon increasing the pH above the pKa of the DMAEMA groups. A dramatic change in 19F MRI imaging intensity was observed on passing from an alkaline to an acidic environment. These results indicate that these 19F detectable and pH-sensitive star polymer nanoparticles are promising as 19F MRI “smart” contrast agents for selective imaging.
Keyword Raft dispersion polymerization
Living radical polymerization
Magnetic-resonance signals
Copolymer nanoparticles
Click chemistry
Drug-delivery
Core
Protein
Water
Micelles
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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