Heterozygosity for Nuclear Factor One X Affects Hippocampal-Dependent Behaviour in Mice

Harris, Lachlan, Dixon, Chantelle, Cato, Kathleen, Heng, Yee Hsieh Evelyn, Kurniawan, Nyoman D., Ullmann, Jeremy F. P., Janke, Andrew L., Gronostajski, Richard M., Richards, Linda J., Burne, Thomas H. J. and Piper, Michael (2013) Heterozygosity for Nuclear Factor One X Affects Hippocampal-Dependent Behaviour in Mice. PLoS ONE, 8 6: . doi:10.1371/journal.pone.0065478


Author Harris, Lachlan
Dixon, Chantelle
Cato, Kathleen
Heng, Yee Hsieh Evelyn
Kurniawan, Nyoman D.
Ullmann, Jeremy F. P.
Janke, Andrew L.
Gronostajski, Richard M.
Richards, Linda J.
Burne, Thomas H. J.
Piper, Michael
Title Heterozygosity for Nuclear Factor One X Affects Hippocampal-Dependent Behaviour in Mice
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0065478
Open Access Status DOI
Volume 8
Issue 6
Total pages 15
Place of publication San Francisco, CA United States
Publisher Public Library of Science
Collection year 2014
Language eng
Formatted abstract
Identification of the genes that regulate the development and subsequent functioning of the hippocampus is pivotal to understanding the role of this cortical structure in learning and memory. One group of genes that has been shown to be critical for the early development of the hippocampus is the Nuclear factor one (Nfi) family, which encodes four site-specific transcription factors, NFIA, NFIB, NFIC and NFIX. In mice lacking Nfia, Nfib or Nfix, aspects of early hippocampal development, including neurogenesis within the dentate gyrus, are delayed. However, due to the perinatal lethality of these mice, it is not clear whether this hippocampal phenotype persists to adulthood and affects hippocampal-dependent behaviour. To address this we examined the hippocampal phenotype of mice heterozygous for Nfix (Nfix+/-), which survive to adulthood. We found that Nfix+/- mice had reduced expression of NFIX throughout the brain, including the hippocampus, and that early hippocampal development in these mice was disrupted, producing a phenotype intermediate to that of wild-type mice and Nfix-/- mice. The abnormal hippocampal morphology of Nfix+/- mice persisted to adulthood, and these mice displayed a specific performance deficit in the Morris water maze learning and memory task. These findings demonstrate that the level of Nfix expression during development and within the adult is essential for the function of the hippocampus during learning and memory.
Keyword Dna Binding/dimerization Domain
Protein Messenger Rna
Morris Water Maze
Sotos Like
Developmental Expression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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