Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle

Wang, Shu-Ching Mary and Muscat, George E. O. (2013) Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle. IUBMB Life, 65 8: 657-664. doi:10.1002/iub.1181


Author Wang, Shu-Ching Mary
Muscat, George E. O.
Title Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle
Journal name IUBMB Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2013-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/iub.1181
Volume 65
Issue 8
Start page 657
End page 664
Total pages 8
Place of publication United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2014
Language eng
Formatted abstract
Glycogen is an energy storage depot for the mammalian species. This review focuses on recent developments that have identified the role of nuclear hormone receptor (NR) signaling and epigenomic control in the regulation of important genes that modulate glycogen metabolism. Specifically, new studies have revealed that the NR4A subgroup (of the NR superfamily) are strikingly sensitive to beta-adrenergic stimulation in skeletal muscle, and transgenic studies in mice have revealed the expression of these NRs affects endurance and glycogen levels in muscle. Furthermore, other studies have demonstrated that one of the NR coregulator class of enzymes that mediate chromatin remodeling, the histone methyltransferases (for example, protein arginine methyltransferase 4) regulates the expression of several genes involved in glycogen metabolism and glycogen storage diseases in skeletal muscle. Importantly, NRs and histone methyltransferases, have the potential to be pharmacologically exploited and may provide novel targets in the quest to treat disorders of glycogen storage.
Keyword Glycogen
Nuclear receptors
Protein arginine methylation
PGC-1-alpha messenger-RNA
Myocyte enhancer factor-2
Gene-expression
Storage diseases
Exercise intensity
Pompe-disease
Activation
Cells
Methyltransferases
PGC-1ɑ
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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