Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia

Barwood, Caroline H. S., Murdoch, Bruce E., Riek, Stephan, O'Sullivan, John D., Wong, Andrew, Lloyd, David and Coulthard, Alan (2013) Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia. Neurorehabilitation, 32 4: 915-928. doi:10.3233/NRE-130915


Author Barwood, Caroline H. S.
Murdoch, Bruce E.
Riek, Stephan
O'Sullivan, John D.
Wong, Andrew
Lloyd, David
Coulthard, Alan
Title Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia
Journal name Neurorehabilitation   Check publisher's open access policy
ISSN 1053-8135
1878-6448
Publication date 2013-01
Year available 2013
Sub-type Article (original research)
DOI 10.3233/NRE-130915
Volume 32
Issue 4
Start page 915
End page 928
Total pages 14
Place of publication Amsterdam, The Netherlands
Publisher I O S Press
Collection year 2014
Language eng
Formatted abstract
BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) has emerged as a potential therapeutic tool for the rehabilitation of language in chronic non-fluent aphasia post-stroke. Previous studies report that low frequency (1 Hz) rTMS applied to homologous language sites can facilitate behavioural language changes. Improvements in picture naming performance and speech output are frequently reported.

OBJECTIVES: This study aims to assess the efficacy of inhibitory rTMS to modulate language performance in non-fluent aphasia.

METHODS: Low-frequency (1 Hz) rTMS was applied to six active stimulation and six placebo patients for 20 min per day over 10 days, as outlined in a previous published investigation. Behavioural language outcome measures were taken at baseline (pre-stimulation) and 1 week, 2 months, 8 months and 12 months post-stimulation.

RESULTS: The findings demonstrate treatment-related changes observed in the stimulation group, up to 12 months post-stimulation, when compared to the placebo control group over time for naming performance, expressive language and auditory comprehension.

CONCLUSION
: These outcomes provide considerable evidence to support the theory of rTMS modulating mechanisms of transcallosal disinhibition in the aphasic brain, and highlight the potential clinical application of rTMS for language rehabilitation in chronic aphasia.
Keyword Non fluent aphasia
Aphasia
Transcranial magnetic stimulation
Tms
Rehabilitation
Stroke
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Health and Rehabilitation Sciences Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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