An influenza virus-inspired polymer system for the timed release of siRNA

Truong, Nghia P., Gu, Wenyi, Prasadam, Indira, Jia, Zhongfan, Crawford, Ross, Xiao, Yin and Monteiro, Michael J. (2013) An influenza virus-inspired polymer system for the timed release of siRNA. Nature Communications, 4 . doi:10.1038/ncomms2905

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Author Truong, Nghia P.
Gu, Wenyi
Prasadam, Indira
Jia, Zhongfan
Crawford, Ross
Xiao, Yin
Monteiro, Michael J.
Title An influenza virus-inspired polymer system for the timed release of siRNA
Journal name Nature Communications   Check publisher's open access policy
ISSN 2041-1723
Publication date 2013-05-21
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ncomms2905
Open Access Status File (Publisher version)
Volume 4
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is susceptible to degradation by plasma and tissue nucleases and due to its negative charge unable to cross the cell membrane. Here we report a new polymer carrier designed to mimic the influenza virus escape mechanism from the endosome, followed by a timed release of the small interfering RNA in the cytosol through a self-catalyzed polymer degradation process. Our polymer changes to a negatively charged and non-toxic polymer after the release of small interfering RNA, presenting potential for multiple repeat doses and long-term treatment of diseases.
Keyword Gene delivery
Cationic polymer
DNA
Therapeutics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 1902

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
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Created: Sun, 11 Aug 2013, 00:23:16 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology