Precursor De13.1 from Conus delessertii defines the novel G gene superfamily

Aguilar, Manuel B., Ortiz, Ernesto, Kaas, Quentin, Lopez-Vera, Estuardo, Becerril, Baltazar, Possani, Lourival D. and Heimer de la Cotera, Edgar P. (2013) Precursor De13.1 from Conus delessertii defines the novel G gene superfamily. Peptides, 41 17-20. doi:10.1016/j.peptides.2013.01.009


Author Aguilar, Manuel B.
Ortiz, Ernesto
Kaas, Quentin
Lopez-Vera, Estuardo
Becerril, Baltazar
Possani, Lourival D.
Heimer de la Cotera, Edgar P.
Title Precursor De13.1 from Conus delessertii defines the novel G gene superfamily
Formatted title
Precursor De13.1 from Conus delessertii defines the novel G gene superfamily
Journal name Peptides   Check publisher's open access policy
ISSN 0196-9781
1873-5169
Publication date 2013-03
Sub-type Article (original research)
DOI 10.1016/j.peptides.2013.01.009
Volume 41
Start page 17
End page 20
Total pages 4
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Peptide de13a was previously purified from the venom of the worm-hunting cone snail Conus delessertii from the Yucatán Channel, México. This peptide has eight cysteine (Cys) residues in the unique arrangement CCCCCCCC, which defines the cysteine framework XIII ("" represents one or more non-Cys residues). Remarkably, δ-hydroxy-lysine residues have been found only in conotoxin de13a, which also contains an unusually high proportion of hydroxylated amino acid residues. Here, we report the cDNA cloning of the complete precursor De13.1 of a related peptide, de13b, which has the same Cys framework and inter-Cys spacings as peptide de13a, and shares high protein/nucleic acid sequence identity (87%/90%) with de13a, suggesting that both peptides belong to the same conotoxin gene superfamily. Analysis of the signal peptide of precursor De13.1 reveals that this precursor belongs to a novel conotoxin gene superfamily that we chose to name gene superfamily G. Thus far superfamily G only includes two peptides, each of which contains the same, distinctive Cys framework and a high proportion of amino acid residues with hydroxylated side chains.
Keyword Conidae
Conopeptide
Conotoxin
Conus delessertii
Hydroxy-lysine
Peptide de13b
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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