Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer

Nagle, C. M., Marquart, L., Bain, C. J., O'Brien, S., Lahmann, P. H., Quinn, M., Oehler, M. K., Obermair, A., Spurdle, A. B. and Webb, P. M. (2013) Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer. European Journal of Cancer, 49 12: 2717-2726. doi:10.1016/j.ejca.2013.03.015

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Author Nagle, C. M.
Marquart, L.
Bain, C. J.
O'Brien, S.
Lahmann, P. H.
Quinn, M.
Oehler, M. K.
Obermair, A.
Spurdle, A. B.
Webb, P. M.
Title Impact of weight change and weight cycling on risk of different subtypes of endometrial cancer
Journal name European Journal of Cancer   Check publisher's open access policy
ISSN 0959-8049
Publication date 2013-08
Sub-type Article (original research)
DOI 10.1016/j.ejca.2013.03.015
Open Access Status
Volume 49
Issue 12
Start page 2717
End page 2726
Total pages 10
Place of publication United Kingdom
Publisher Pergamon
Collection year 2014
Language eng
Formatted abstract
Aim Obesity is an established risk factor for endometrial cancer. Associations tend to be stronger for the endometrioid subtype. The role of adult weight change and weight cycling is uncertain. Our study aimed to determine whether there is an association between different adult weight trajectories, weight cycling and risk of endometrial cancer overall, and by subtype.

Methods We analysed data from the Australian National Endometrial Cancer study, a population-based case–control study that collected self-reported information on height, weight at three time points (age 20, maximum and 1 year prior to diagnosis [recent]), intentional weight loss/regain (weight cycling) from 1398 women with endometrial cancer and 1538 controls. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable logistic regression analysis.

Results Relative to women who maintained a stable weight during adulthood, greater weight gain after the age of 20 was associated with increased risk of endometrial cancer (OR for gain 40+kg all subtypes 5.3, 95% CI 3.9–7.3; endometrioid 6.5, 95% CI 4.7–9.0). The strongest associations were observed among women who were continually overweight from the age of 20 (all subtypes OR 3.6, 95% CI 2.6–5.0). Weight cycling was associated with increased risk, particularly among women who had ever been obese (OR 2.9 95% CI 1.8–4.7), with ∼3-fold risks seen for both endometrioid and non-endometrioid tumour subtypes. Women who had intentionally lost weight and maintained that weight loss were not at increased risk.

Conclusion These results suggest that higher adult weight gain, and perhaps weight cycling, independently increase the risk of endometrial cancer, however women who lost weight and kept that weight off were not at increased risk.
Keyword Weight cycling
Weight change
Body mass index
Endometrial cancer
Histologic subtype
Gastric bypass-surgery
Body-fat distribution
Bariatric surgery
Incidence trends
Older women
Mass index
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
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