Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies

Palmer, Suetonia, Vecchio, Mariacristina, Craig, Jonathan C., Tonelli, Marcello, Johnson, David W., Nicolucci, Antonio, Pellegrini, Fabio, Saglimbene, Valeria, Logroscino, Giancarlo, Fishbane, Steven and Strippoli, Giovanni F. M. (2013) Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies. Kidney International, 84 1: 179-191. doi:10.1038/ki.2013.77


Author Palmer, Suetonia
Vecchio, Mariacristina
Craig, Jonathan C.
Tonelli, Marcello
Johnson, David W.
Nicolucci, Antonio
Pellegrini, Fabio
Saglimbene, Valeria
Logroscino, Giancarlo
Fishbane, Steven
Strippoli, Giovanni F. M.
Title Prevalence of depression in chronic kidney disease: systematic review and meta-analysis of observational studies
Journal name Kidney International   Check publisher's open access policy
ISSN 0085-2538
1523-1755
Publication date 2013-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ki.2013.77
Volume 84
Issue 1
Start page 179
End page 191
Total pages 13
Place of publication United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Formatted abstract
Prevalence estimates of depression in chronic kidney disease (CKD) vary widely in existing studies. We conducted a systematic review and meta-analysis of observational studies to summarize the point prevalence of depressive symptoms in adults with CKD. We searched MEDLINE and Embase (through January 2012). Random-effects meta-analysis was used to estimate the prevalence of depressive symptoms. We also limited the analyses to studies using clinical interview and prespecified criteria for diagnosis. We included 249 populations (55,982 participants). Estimated prevalence of depression varied by stage of CKD and the tools used for diagnosis. Prevalence of interview-based depression in CKD stage 5D was 22.8% (confidence interval (CI), 18.6–27.6), but estimates were somewhat less precise for CKD stages 1–5 (21.4% (CI, 11.1–37.2)) and for kidney transplant recipients (25.7% (12.8–44.9)). Using self- or clinician-administered rating scales, the prevalence of depressive symptoms for CKD stage 5D was higher (39.3% (CI, 36.8–42.0)) relative to CKD stages 1–5 (26.5% (CI, 18.5–36.5)) and transplant recipients (26.6% (CI, 20.9–33.1)) and suggested that self-report scales may overestimate the presence of depression, particularly in the dialysis setting. Thus, interview-defined depression affects approximately one-quarter of adults with CKD. Given the potential prevalence of depression in the setting of CKD, randomized trials to evaluate effects of interventions for depression on patient-centered outcomes are needed.
Keyword Depression
Dialysis
Quality of life
Quality-of-life
Stage renal-disease
Chronic-hemodialysis patients
Japan dialysis outcomes
Major depression
Follow-up
Psychiatric-disorders
Nutritional-status
Practice patterns
Symptoms predict
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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