Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin

Byrne, E. M., Carrillo-Roa, T., Henders, A. K., Bowdler, L., McRae, A. F., Heath, A. C., Martin, N. G., Montgomery, G. W., Krause, L. and Wray, N. R. (2013) Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin. Translational Psychiatry, 3 e269.1-e269.6. doi:10.1038/tp.2013.45

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Author Byrne, E. M.
Carrillo-Roa, T.
Henders, A. K.
Bowdler, L.
McRae, A. F.
Heath, A. C.
Martin, N. G.
Montgomery, G. W.
Krause, L.
Wray, N. R.
Title Monozygotic twins affected with major depressive disorder have greater variance in methylation than their unaffected co-twin
Journal name Translational Psychiatry   Check publisher's open access policy
ISSN 2158-3188
Publication date 2013-06
Sub-type Article (original research)
DOI 10.1038/tp.2013.45
Open Access Status DOI
Volume 3
Start page e269.1
End page e269.6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract Our understanding of major depressive disorder (MDD) has focused on the influence of genetic variation and environmental risk factors. Growing evidence suggests the additional role of epigenetic mechanisms influencing susceptibility for complex traits. DNA sequence within discordant monozygotic twin (MZT) pairs is virtually identical; thus, they represent a powerful design for studying the contribution of epigenetic factors to disease liability. The aim of this study was to investigate whether specific methylation profiles in white blood cells could contribute to the aetiology of MDD. Participants were drawn from the Queensland Twin Registry and comprised 12 MZT pairs discordant for MDD and 12 MZT pairs concordant for no MDD and low neuroticism. Bisulphite treatment and genome-wide interrogation of differentially methylated CpG sites using the Illumina Human Methylation 450 BeadChip were performed in WBC-derived DNA. No overall difference in mean global methylation between cases and their unaffected co-twins was found; however, the differences in females was significant (P=0.005). The difference in variance across all probes between affected and unaffected twins was highly significant (P<2.2×10-16), with 52.4% of probes having higher variance in cases (binomial P-value<2. 2×10-16). No significant differences in methylation were observed between discordant MZT pairs and their matched concordant MZT (permutation minimum P=0.11) at any individual probe. Larger samples are likely to be needed to identify true associations between methylation differences at specific CpG sites.
Keyword Depression
Epigenetics
MDD
Methylation
Twins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number e269

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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