Glucose homeostasis can be differentially modulated by varying individual components of a western diet

Forbes, Josephine M., Cowan, Samantha P., Andrikopoulos, Sofianos, Morley, Amy L., Ward, Leigh C., Walker, Karen Z., Cooper, Mark E. and Coughlan, Melinda T. (2013) Glucose homeostasis can be differentially modulated by varying individual components of a western diet. Journal of Nutritional Biochemistry, 24 7: 1251-1257. doi:10.1016/j.jnutbio.2012.09.009

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Author Forbes, Josephine M.
Cowan, Samantha P.
Andrikopoulos, Sofianos
Morley, Amy L.
Ward, Leigh C.
Walker, Karen Z.
Cooper, Mark E.
Coughlan, Melinda T.
Title Glucose homeostasis can be differentially modulated by varying individual components of a western diet
Journal name Journal of Nutritional Biochemistry   Check publisher's open access policy
ISSN 0955-2863
Publication date 2013-07
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jnutbio.2012.09.009
Open Access Status File (Author Post-print)
Volume 24
Issue 7
Start page 1251
End page 1257
Total pages 7
Place of publication New York United States
Publisher Elseiver Inc
Collection year 2014
Language eng
Abstract Chronic overconsumption of a Western diet has been identified as a major risk factor for diabetes, yet precisely how each individual component contributes to defects in glucose homeostasis independent of consumption of other macronutrients remains unclear. Eight-week-old male Sprague Dawley rats were randomized to feeding with one of six semi-pure diets: control, processed (high advanced glycation end products/AGE), high protein, high dextrose (glucose polymer), high in saturated fat (plant origin), or high in saturated fat (animal origin). After chronic feeding for 24 weeks, body composition was determined by bioelectrical impedance spectroscopy and glucose homeostasis was assessed. When compared to the control and high AGE diets, excess consumption of the diet high in saturated fat (animal source) increased body weight and adiposity, and decreased insulin sensitivity, as defined by HOMA IR, impaired skeletal muscle insulin signaling and insulin hypersecretion in the context of increased circulating glucagon-like peptide (GLP-1). Compared to the control diet, chronic consumption of the high AGE, protein or dextrose diet increased fasting plasma glucose, decreased fasting plasma insulin and insulin secretion. These diets also reduced circulating GLP-1 concentrations. These data suggest that individual components of a western diet have differential effects in modulating glucose homeostasis and adiposity. These data provide clear evidence of a link between over-consumption of a western diet and the development of diabetes.
Keyword Advanced glycation end products
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
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