MRI biomarkers for post-traumatic epileptogenesis

Immonen, Riikka, Kharatishvili, Irina, Gröhn, Olli and Pitkänen, Asla (2013) MRI biomarkers for post-traumatic epileptogenesis. Journal of Neurotrauma, 30 14: 1305-1309. doi:10.1089/neu.2012.2815

Author Immonen, Riikka
Kharatishvili, Irina
Gröhn, Olli
Pitkänen, Asla
Title MRI biomarkers for post-traumatic epileptogenesis
Journal name Journal of Neurotrauma   Check publisher's open access policy
ISSN 0897-7151
Publication date 2013-07-15
Sub-type Article (original research)
DOI 10.1089/neu.2012.2815
Volume 30
Issue 14
Start page 1305
End page 1309
Total pages 5
Place of publication New Rochelle, NY United States
Publisher Mary Ann Liebert, Publishers
Collection year 2014
Language eng
Formatted abstract
The present study tested a hypothesis that early identification of injury severity with quantitative magnetic resonance imaging (MRI) provides biomarkers for predicting increased seizure susceptibility and epileptogenesis after traumatic brain injury (TBI). TBI was induced by lateral fluid percussion injury (FPI) in adult rats. Quantitative T2, T1𝜌, and diffusion were assessed with MRI at 9 days, 23 days, or 2 months post-TBI in the perilesional cortex, thalamus, and hippocampus. Seizure susceptibility was assessed at 12 months after TBI using the pentylenetetrazol seizure-susceptibility test. At 9 and 23 days post-TBI, a change in T1𝜌 of the perilesional cortex showed the greatest predictive value for increased seizure susceptibility at 12 months post-TBI [area under the curve (AUC), 0.929 and 0.952, respectively; p<0.01]. At 2 months post-TBI, Dav in the thalamus was the best of the biomarkers analyzed (AUC, 0.988; p<0.05). The highest predictive value of all biomarkers was achieved by combining the measurement of Dav in the perilesional cortex and the thalamus at 2 months post-TBI (AUC, 1.000; p<0.01). Our results provide proof-of-concept evidence that clinically relevant MRI biomarkers predict increased seizure susceptibility after experimental TBI.
Keyword Epilepsy
Magnetic resonance imaging
Traumatic brain injury
Seizure susceptibility
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Centre for Advanced Imaging Publications
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