Pitfalls of predicting complex traits from SNPs

Wray, Naomi R., Yang, Jian, Hayes, Ben J., Price, Alkes L., Goddard, Michael E. and Visscher, Peter M. (2013) Pitfalls of predicting complex traits from SNPs. Nature Reviews Genetics, 14 7: 507-515. doi:10.1038/nrg3457

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Author Wray, Naomi R.
Yang, Jian
Hayes, Ben J.
Price, Alkes L.
Goddard, Michael E.
Visscher, Peter M.
Title Pitfalls of predicting complex traits from SNPs
Journal name Nature Reviews Genetics   Check publisher's open access policy
ISSN 1471-0056
1471-0064
Publication date 2013-07
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrg3457
Open Access Status File (Author Post-print)
Volume 14
Issue 7
Start page 507
End page 515
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Abstract The success of genome-wide association studies (GWASs) has led to increasing interest in making predictions of complex trait phenotypes, including disease, from genotype data. Rigorous assessment of the value of predictors is crucial before implementation. Here we discuss some of the limitations and pitfalls of prediction analysis and show how naive implementations can lead to severe bias and misinterpretation of results.
Keyword Genome-wide association
Risk prediction
Common SNPs
Natural selection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 121 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 125 times in Scopus Article | Citations
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