Transthyretin and the human placenta

Landers, K. A., Mortimer, R. H. and Richard, K. (2013) Transthyretin and the human placenta. Placenta, 34 7: 513-517. doi:10.1016/j.placenta.2013.04.013


Author Landers, K. A.
Mortimer, R. H.
Richard, K.
Title Transthyretin and the human placenta
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 2013-07
Sub-type Article (original research)
DOI 10.1016/j.placenta.2013.04.013
Volume 34
Issue 7
Start page 513
End page 517
Total pages 5
Place of publication Camden, London, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Since its discovery, transthyretin (TTR) has been regarded as an important hepatically derived protein carrier of thyroid hormones and retinol in blood. However, in more recent years it has been shown that TTR has other important functions. TTR is abundant in cerebrospinal fluid, where it may be involved in transport of thyroid hormones into the brain. TTR derived amyloid is associated with diseases such as senile systemic amyloidosis, familial amyloid polyneuropathy and familial amyloid cardiomyopathy.

Recently, synthesis, secretion and uptake of TTR by human placenta have been reported. TTR appears to play an important role in the delivery of maternal thyroid hormone to the developing fetus. This review explores the various proposed roles of TTR and more recent findings on TTR synthesis and expression in the placenta.
Keyword Transthyretin
Placenta
Thyroid hormone
Binding-protein transthyretin
Choroid-plexus
Thyroxine-binding
Cerebrospinal-fluid
Messenger-RNA
Transcription factors
Alzheimers-disease
Early-pregnancy
Pre-albumin
Rat-brain
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
ERA White List Items
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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