Transthyretin-thyroid hormone internalization by trophoblasts

Landers, K. A., Li, H., Subramaniam, V. N., Mortimer, R. H. and Richard, K. (2013) Transthyretin-thyroid hormone internalization by trophoblasts. Placenta, 34 8: 716-718. doi:10.1016/j.placenta.2013.05.005

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Author Landers, K. A.
Li, H.
Subramaniam, V. N.
Mortimer, R. H.
Richard, K.
Title Transthyretin-thyroid hormone internalization by trophoblasts
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2013-08
Sub-type Article (original research)
DOI 10.1016/j.placenta.2013.05.005
Open Access Status
Volume 34
Issue 8
Start page 716
End page 718
Total pages 3
Place of publication United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization.

TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process.
Keyword Thyroid hormone
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Sun, 11 Aug 2013, 00:04:08 EST by System User on behalf of School of Medicine