Early gestational exposure to moderate concentrations of ethanol alters adult behaviour in C57BL/6J mice

Sanchez Vega, Michelle C., Chong, Suyinn and Burne, Thomas H. J. (2013) Early gestational exposure to moderate concentrations of ethanol alters adult behaviour in C57BL/6J mice. Behavioural Brain Research, 252 326-333. doi:10.1016/j.bbr.2013.06.003

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Author Sanchez Vega, Michelle C.
Chong, Suyinn
Burne, Thomas H. J.
Title Early gestational exposure to moderate concentrations of ethanol alters adult behaviour in C57BL/6J mice
Journal name Behavioural Brain Research   Check publisher's open access policy
ISSN 0166-4328
Publication date 2013-09
Sub-type Article (original research)
DOI 10.1016/j.bbr.2013.06.003
Open Access Status File (Author Post-print)
Volume 252
Start page 326
End page 333
Total pages 8
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2014
Language eng
Abstract Alcohol consumption during pregnancy has deleterious effects on the developing foetus ranging from subtle physical deficits to severe behavioural abnormalities and is encompassed under a broad umbrella term, foetal alcohol spectrum disorders (FASD). High levels of exposure show distinct effects, whereas the consequences of moderate exposures have been less well studied. The aim of this study was to examine the effects of a moderate dose ethanol exposure using an ad libitum drinking procedure during the first eight days of gestation in mice on the behavioural phenotype of adult offspring. Adult female C57Bl/6J mice were mated and exposed to either 10% (v/v) ethanol or water for the first 8 days of gestation (GD 0-8), and then offered water for the rest of gestation. Early developmental milestone achievement was assessed in offspring at postnatal days (P) 7, 14 and 21. Adult offspring underwent a comprehensive battery of behavioural tests to examine a range of behavioural domains including locomotion, exploration, anxiety, social behaviour, learned helplessness, sensorimotor gating, and nociception, as well as spatial memory in a water maze. Ethanol-exposed mice had similar postnatal developmental trajectories to water-exposed mice. However, the ethanol-exposed mice showed increased hyperlocomotion at P 14, 21 and 70 (p<. 0.05). Increased exploration and heightened motivation were also observed in adult mice. Furthermore, ethanol-exposed mice showed a significant improvement in memory in the water maze. The main findings were that mice had persistent and long lasting alterations in behaviour, including hyperactivity and enhanced spatial memory. These data suggest that even moderate dose ethanol exposure in early gestation has long term consequences on brain function and behaviour in mice.
Keyword Animal model
Brain function
Fetal alcohol exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 05 Aug 2013, 09:13:15 EST by Debra McMurtrie on behalf of Queensland Brain Institute