On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory

Li, Xiang, Wei, Wei, Ratnu, Vikram and Bredy, Timothy (2013) On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory. Neurobiology of Learning and Memory, 105 125-132. doi:10.1016/j.nlm.2013.06.009


Author Li, Xiang
Wei, Wei
Ratnu, Vikram
Bredy, Timothy
Title On the potential role of active DNA demethylation in establishing epigenetic states associated with neural plasticity and memory
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
1095-9564
Publication date 2013
Sub-type Article (original research)
DOI 10.1016/j.nlm.2013.06.009
Volume 105
Start page 125
End page 132
Total pages 8
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2014
Language eng
Abstract Dynamic variations in DNA methylation regulate neuronal gene expression in an experience-dependent manner. Although DNA methylation has been implicated in synaptic plasticity, learning and memory, active DNA demethylation is also induced by learning, which suggests that an interaction between the two processes is necessary for cognitive function. Active DNA demethylation is a complex process involving a variety of proteins and epigenetic regulatory enzymes, the understanding of which with respect to its role in the adult brain is in its infancy. We here provide an overview of the current understanding of active DNA demethylation, and describe how this process may establish persistent epigenetic states that are associated with neural plasticity and memory formation.
Keyword Active DNA demethylation
Epigenetic
Memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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Created: Mon, 05 Aug 2013, 09:02:35 EST by Debra McMurtrie on behalf of Queensland Brain Institute