Nuclear factor one X regulates Bobby Sox during development of the mouse forebrain

Dixon, Chantelle, Harvey, Tracey, Smith, Aaron G., Gronostajski, Richard M., Bailey, Timothy L. and Piper, Michael (2013) Nuclear factor one X regulates Bobby Sox during development of the mouse forebrain. Cellular and Molecular Neurobiology, 33 7: 867-873. doi:10.1007/s10571-013-9961-4

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Author Dixon, Chantelle
Harvey, Tracey
Smith, Aaron G.
Gronostajski, Richard M.
Bailey, Timothy L.
Piper, Michael
Title Nuclear factor one X regulates Bobby Sox during development of the mouse forebrain
Journal name Cellular and Molecular Neurobiology   Check publisher's open access policy
ISSN 0272-4340
Publication date 2013-07-14
Sub-type Article (original research)
DOI 10.1007/s10571-013-9961-4
Open Access Status File (Author Post-print)
Volume 33
Issue 7
Start page 867
End page 873
Total pages 7
Place of publication New York, NY, United States
Publisher Springer
Collection year 2014
Language eng
Formatted abstract
The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix −/− mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 14 July 2013.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Thu, 01 Aug 2013, 10:26:25 EST by Susan Allen on behalf of Institute for Molecular Bioscience