Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?

Filippich, Cheryl, Wolvetang, Ernst J. and Mowry, Bryan J. (2013) Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?. Schizophrenia Bulletin, 39 5: 948-954. doi:10.1093/schbul/sbt103


Author Filippich, Cheryl
Wolvetang, Ernst J.
Mowry, Bryan J.
Title Will brain cells derived from induced pluripotent stem cells or directly converted from somatic cells (iNs) be useful for schizophrenia research?
Journal name Schizophrenia Bulletin   Check publisher's open access policy
ISSN 0586-7614
1745-1701
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1093/schbul/sbt103
Volume 39
Issue 5
Start page 948
End page 954
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Formatted abstract
The reprogramming of nonneuronal somatic cells to induced pluripotent stem cells and their derivation to functional brain cells as well as the related methods for direct conversion of somatic cells to neurons have opened up the possibility of conducting research on cellular disease models from living schizophrenia patients. We review the published literature on schizophrenia that has used this rapidly developing technology, highlighting the need for specific aims and reproducibility. The key issues for consideration for future schizophrenia research in this field are discussed and potential investigations using this technology are put forward for critical assessment by the reader.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Wed, 31 Jul 2013, 12:10:50 EST by Debra McMurtrie on behalf of Queensland Brain Institute