Perceptual and response interference in Alzheimer's disease and mild cognitive impairment

Wang, Pan, Zhang, Xin, Liu, Yong, Liu, Sainan, Zhou, Bo, Zhang, Zengqiang, Yao, Hongxiang, Zhang, Xi and Jiang, Tianzi (2013) Perceptual and response interference in Alzheimer's disease and mild cognitive impairment. Clinical Neurophysiology, 124 12: 2389-2396. doi:10.1016/j.clinph.2013.05.014

Author Wang, Pan
Zhang, Xin
Liu, Yong
Liu, Sainan
Zhou, Bo
Zhang, Zengqiang
Yao, Hongxiang
Zhang, Xi
Jiang, Tianzi
Title Perceptual and response interference in Alzheimer's disease and mild cognitive impairment
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1388-2457
Publication date 2013-12
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.clinph.2013.05.014
Open Access Status
Volume 124
Issue 12
Start page 2389
End page 2396
Total pages 8
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Objectives: The ability to resolve conflicts is indispensable to the function of daily life and decreases with cognitive decline. We hypothesized that subjects with different levels of cognitive impairment exhibit different conflict resolution performances and may be susceptible to interference effects at different stages.

Methods: Sixteen normal controls (NC), 15 mild cognitive impairment (MCI) and seven Alzheimer's disease (AD) patients were recruited to perform in a modified Eriksen flanker task.

Results: We observed that the AD and MCI patients exhibited smaller accuracy rate and longer response time compared to NC subjects. Longer N2 and P300 latencies were observed in the AD group. Furthermore, the MCI group showed a longer latency than the NC group in the P300 latency. The magnitude of the perceptual and response interference effects was larger in the AD group than the other groups, and the MCI group significantly differed from the NC group at the perceptual level.

Conclusion: The ability to resolve conflict decreased with impaired cognition and the perceptual and response interference effects may be useful in distinguishing MCI and AD. Significance: The perceptual or response interference effect may potentially be employed as a useful non-invasive probe for the clinical diagnosis of MCI and AD.
Keyword Alzheimer's disease
Event-related potential
Flanker task
Perceptual processes
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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Created: Tue, 30 Jul 2013, 12:25:13 EST by Debra McMurtrie on behalf of Queensland Brain Institute