Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion

Fothergill, Thomas, Donahoo, Amber-Lee S., Douglass, Amelia, Zalucki, Oressia, Yuan, Jiajia, Shu, Tianzhi, Goodhill, Geoffrey J. and Richards, Linda J. (2014) Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion. Cerebral Cortex, 24 5: 1138-1151. doi:10.1093/cercor/bhs395

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Author Fothergill, Thomas
Donahoo, Amber-Lee S.
Douglass, Amelia
Zalucki, Oressia
Yuan, Jiajia
Shu, Tianzhi
Goodhill, Geoffrey J.
Richards, Linda J.
Title Netrin-DCC signaling regulates corpus callosum formation through attraction of pioneering axons and by modulating Slit2-mediated repulsion
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
1460-2199
Publication date 2014
Year available 2013
Sub-type Article (original research)
DOI 10.1093/cercor/bhs395
Open Access Status File (Author Post-print)
Volume 24
Issue 5
Start page 1138
End page 1151
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Collection year 2014
Language eng
Abstract The left and right sides of the nervous system communicate via commissural axons that cross the midline during development using evolutionarily conserved molecules. These guidance cues have been particularly well studied in the mammalian spinal cord, but it remains unclear whether these guidance mechanisms for commissural axons are similar in the developing forebrain, in particular for the corpus callosum, the largest and most important commissure for cortical function. Here, we show that Netrin1 initially attracts callosal pioneering axons derived from the cingulate cortex, but surprisingly is not attractive for the neocortical callosal axons that make up the bulk of the projection. Instead, we show that Netrin-deleted in colorectal cancer signaling acts in a fundamentally different manner, to prevent the Slit2-mediated repulsion of precrossing axons thereby allowing them to approach and cross the midline. These results provide the first evidence for how callosal axons integrate multiple guidance cues to navigate the midline.
Keyword Axon guidance
Commissure formation
Corpus callosum
Cortical development
DCC
Neocortex
Robo1
Silencing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 16 times in Scopus Article | Citations
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Created: Tue, 30 Jul 2013, 11:55:50 EST by Debra McMurtrie on behalf of Queensland Brain Institute