Sensorimotor circuitry involved in the higher brain control of coughing.

Mazzone, Start B., McGovern, Alice E., Yang, Seung-Kwon, Woo, Ariel, Phipps, Simon, Ando, Ayaka, Leech, Jennifer and Farrell, Michael J. (2013) Sensorimotor circuitry involved in the higher brain control of coughing.. Cough, 9 1: 7.1-7.4. doi:10.1186/1745-9974-9-7


Author Mazzone, Start B.
McGovern, Alice E.
Yang, Seung-Kwon
Woo, Ariel
Phipps, Simon
Ando, Ayaka
Leech, Jennifer
Farrell, Michael J.
Title Sensorimotor circuitry involved in the higher brain control of coughing.
Journal name Cough   Check publisher's open access policy
ISSN 1745-9974
Publication date 2013-03-06
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1745-9974-9-7
Open Access Status DOI
Volume 9
Issue 1
Start page 7.1
End page 7.4
Total pages 5
Place of publication London, United Kingdom
Publisher BioMed Central Ltd
Collection year 2014
Language eng
Formatted abstract
There is an overwhelming body of evidence to support the existence of higher brain circuitries involved in the sensory detection of airways irritation and the motor control of coughing. The concept that cough is purely a reflex response to airways irritation is now superseded by the recognition that perception of an urge-to-cough and altered behavioral modification of coughing are key elements of cough disorders associated with airways disease. Understanding the pathways by which airway sensory nerves ascend into the brain and the patterns of neural activation associated with airways irritation will undoubtedly provide new insights into disordered coughing. This brief review aims to explore our current understanding of higher order cough networks by summarizing data from recent neuroanatomical and functional studies in animals and humans. We provide evidence for the existence of distinct higher order network components involved in the discrimination of signals arising from the airways and the motor control of coughing. The identification of these network components provides a blueprint for future research and the development of targeted managements for cough and the urge-to-cough.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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Created: Mon, 29 Jul 2013, 17:58:57 EST by Dr Stuart Mazzone on behalf of School of Biomedical Sciences