Overweight and obese patients have considerably higher prevalence of most of the major cardiovascular (CV) risk factors, including hypertension (HTN), dyslipidemia (especially high levels of triglycerides [TGs] and lower levels of high-density lipoprotein cholesterol [HDL-C]), type 2 diabetes mellitus (T2DM), and inflammation (especially high levels of C-reactive protein [CRP]) (Lavie et al., 2009a). Additionally, independent of arterial pressure, overweight/obese patients have higher prevalence of left ventricular structural abnormalities, including concentric remodeling and left ventricular hypertrophy, and a higher prevalence of both systolic and diastolic dysfunction (Lavie et al., 2007 and Lavie et al., 2009a). Not surprisingly, almost every CV disease is increased in the setting of overweightness and obesity, including coronary heart disease (CHD), heart failure (HF), atrial fibrillation and peripheral arterial disease (Lavie et al., 2009a). However, despite the adverse effects of overweightness and obesity to increase the prevalence of adverse CV risk factors and CV diseases, now numerous studies have indicated an “obesity paradox,” where overweight and obese patients with various CV diseases generally have a better short- and long-term prognosis than do their lean counterparts (De Schutter et al., 2013, Hamer and Stamatakis, 2013, Lavie et al., 2003, Lavie et al., 2007, Lavie et al., 2009a, Lavie et al., 2009b, Lavie et al., 2011, Lavie et al., 2012 and Lavie et al., 2013b). Although decades ago, this paradox was difficult for scientists and clinicians to accept, now this has been demonstrated in numerous studies and large meta-analyses, making the obesity paradox now difficult to deny...