Sunscreen and Prevention of Skin Aging A Randomized Trial

Hughes, Maria Celia B., Williams, Gail M., Baker, Peter and Green, Adele C. (2013) Sunscreen and Prevention of Skin Aging A Randomized Trial. Annals of Internal Medicine, 158 11: 781-790. doi:10.7326/0003-4819-158-11-201306040-00002

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Author Hughes, Maria Celia B.
Williams, Gail M.
Baker, Peter
Green, Adele C.
Title Sunscreen and Prevention of Skin Aging A Randomized Trial
Journal name Annals of Internal Medicine   Check publisher's open access policy
ISSN 0003-4819
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.7326/0003-4819-158-11-201306040-00002
Volume 158
Issue 11
Start page 781
End page 790
Total pages 12
Place of publication Charlottesville, U.S.A.
Publisher Silverchair Information Systems
Collection year 2014
Language eng
Formatted abstract
Background: Sunscreen use and dietary antioxidants are advocated as preventives of skin aging, but supporting evidence is lacking. Objective: To determine whether regular use of sunscreen compared with discretionary use or β-carotene supplements compared with placebo retard skin aging, measured by degree of photoaging. Design: Randomized, controlled, community-based intervention. (Australian New Zealand Clinical Trials Registry: ACTRN12610000086066). Setting: Nambour, Australia (latitude 26° S). Patients: 903 adults younger than 55 years out of 1621 adults randomly selected from a community register. Intervention: Random assignment into 4 groups: daily use of broad-spectrum sunscreen and 30 mg of β-carotene, daily use of sunscreen and placebo, discretionary use of sunscreen and 30 mg of β-carotene, and discretionary use of sunscreen and placebo. Measurements: Change in microtopography between 1992 and 1996 in the sunscreen and β-carotene groups compared with controls, graded by assessors blinded to treatment allocation. Results: The daily sunscreen group showed no detectable increase in skin aging after 4.5 years. Skin aging from baseline to the end of the trial was 24% less in the daily sunscreen group than in the discretionary sunscreen group (relative odds, 0.76 [95% CI, 0.59 to 0.98]). β-Carotene supplementation had no overall effect on skin aging, although contrasting associations were seen in subgroups with different severity of aging at baseline. Limitation: Some outcome data were missing, and power to detect moderate treatment effects was modest. Conclusion: Regular sunscreen use retards skin aging in healthy, middle-aged men and women. No overall effect of β-carotene on skin aging was identified, and further study is required to definitively exclude potential benefit or potential harm. Primary Funding Source: National Health and Medical Research Council of Australia.
Keyword Sun exposure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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