microRNAs in cardiac development and regeneration

Porrello, Enzo R. (2013) microRNAs in cardiac development and regeneration. Clinical Science, 125 4: 151-166. doi:10.1042/CS20130011

Author Porrello, Enzo R.
Title microRNAs in cardiac development and regeneration
Journal name Clinical Science   Check publisher's open access policy
ISSN 0143-5221
Publication date 2013-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1042/CS20130011
Volume 125
Issue 4
Start page 151
End page 166
Total pages 16
Place of publication United Kingdom
Publisher Portland Press
Collection year 2014
Language eng
Formatted abstract
Heart development involves the precise orchestration of gene expression during cardiac differentiation and morphogenesis by evolutionarily conserved regulatory networks. miRNAs (microRNAs) play important roles in the post-transcriptional regulation of gene expression, and recent studies have established critical functions for these tiny RNAs in almost every facet of cardiac development and disease. The realization that miRNAs are amenable to therapeutic manipulation has also generated considerable interest in the potential of miRNA-based drugs for the treatment of a number of human diseases, including cardiovascular disease. In the present review, I discuss well-established and emerging roles of miRNAs in cardiac development, their relevance to congenital heart disease and unresolved questions in the field for future investigation, as well as emerging therapeutic possibilities for cardiac regeneration.
Keyword Cardiac regeneration
Cardiovascular development
Cardiovascular disease
Congenital heart disease
Non-coding RNA
Embryonic stem-cells
Heart regeneration
Myocardial differentiation
Cardiovascular development
Targeted deletion
miR-15 family
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 35 times in Scopus Article | Citations
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