Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species

Fortes, M. R. S., Reverter, A., Kelly, M., McCulloch, R. and Lehnert, S. A. (2013) Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species. Andrology, 1 4: 644-650. doi:10.1111/j.2047-2927.2013.00101.x

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Fortes, M. R. S.
Reverter, A.
Kelly, M.
McCulloch, R.
Lehnert, S. A.
Title Genome-wide association study for inhibin, luteinizing hormone, insulin-like growth factor 1, testicular size and semen traits in bovine species
Journal name Andrology   Check publisher's open access policy
ISSN 2047-2919
2047-2927
Publication date 2013-07
Sub-type Article (original research)
DOI 10.1111/j.2047-2927.2013.00101.x
Volume 1
Issue 4
Start page 644
End page 650
Total pages 7
Place of publication United States
Publisher Wiley-Blackwell Publishing
Collection year 2014
Language eng
Formatted abstract
The fertility of young bulls impacts on reproduction rates, farm profit and the rate of genetic progress in beef herds. Cattle researchers and industry therefore routinely collect data on the reproductive performance of bulls. Genome-wide association studies were carried out to identify genomic regions and genes associated with reproductive traits measured during the pubertal development of Tropical Composite bulls, from 4 to 24 months of age. Data from 1 085 bulls were collected for seven traits: blood hormone levels of inhibin at 4 months (IN), luteinizing hormone following a gonadotropin releasing hormone challenge at 4 months (LH), insulin-like growth factor 1 at 6 months (IGF1), scrotal circumference at 12 months (SC), sperm motility at 18 months (MOT), percentage of normal spermatozoa at 24 months (PNS) and age at a scrotal circumference of 26 cm (AGE26, or pubertal age). Data from 729 068 single-nucleotide polymorphisms were used in the association analysis. Significant polymorphism associations were discovered for IN, IGF1, SC, AGE26 and PNS. Based on these associations, INHBE, INHBC and HELB are proposed as candidate genes for IN regulation. Polymorphisms associated with IGF1 mapped to the PLAG1 gene region, validating a reported quantitative trait locus on chromosome 14 for IGF1. The X chromosome contained most of the significant associations found for SC, AGE26 and PNS. These findings will contribute to the identification of diagnostic genetic markers and informed genomic selection strategies to assist breeding of cattle with improved fertility. Furthermore, this work provides evidence contributing to gene function annotation in the context of male fertility.
Keyword Bos taurus
Genome-wide association
Male fertility
Reproductive hormones
Sperm quality
Herd reproductive capability
Northern Australia
Different breeds
Beef bulls
Igf-I
Cattle
Puberty
Genes
Expression
Testis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 28 Jul 2013, 00:06:55 EST by System User on behalf of Qld Alliance for Agriculture and Food Innovation