Altered functional connectivity of the primary visual cortex in subjects with amblyopia

Ding, Kun, Liu, Yong, Yan, Xiaohe, Lin, Xiaoming and Jiang, Tianzi (2013) Altered functional connectivity of the primary visual cortex in subjects with amblyopia. Neural Plasticity, 2013 612086.1-612086.8. doi:10.1155/2013/612086

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Author Ding, Kun
Liu, Yong
Yan, Xiaohe
Lin, Xiaoming
Jiang, Tianzi
Title Altered functional connectivity of the primary visual cortex in subjects with amblyopia
Journal name Neural Plasticity   Check publisher's open access policy
ISSN 2090-5904
Publication date 2013-01
Sub-type Article (original research)
DOI 10.1155/2013/612086
Open Access Status DOI
Volume 2013
Start page 612086.1
End page 612086.8
Total pages 8
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Collection year 2014
Language eng
Abstract Amblyopia, which usually occurs during early childhood and results in poor or blurred vision, is a disorder of the visual system that is characterized by a deficiency in an otherwise physically normal eye or by a deficiency that is out of proportion with the structural or functional abnormalities of the eye. Our previous study demonstrated alterations in the spontaneous activity patterns of some brain regions in individuals with anisometropic amblyopia compared to subjects with normal vision. To date, it remains unknown whether patients with amblyopia show characteristic alterations in the functional connectivity patterns in the visual areas of the brain, particularly the primary visual area. In the present study, we investigated the differences in the functional connectivity of the primary visual area between individuals with amblyopia and normal-sighted subjects using resting functional magnetic resonance imaging. Our findings demonstrated that the cerebellum and the inferior parietal lobule showed altered functional connectivity with the primary visual area in individuals with amblyopia, and this finding provides further evidence for the disruption of the dorsal visual pathway in amblyopic subjects.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 612086

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
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Created: Sun, 28 Jul 2013, 00:04:41 EST by System User on behalf of Queensland Brain Institute