GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

Rietveld, Cornelius A., Medland, Sarah E., Derringer, Jaime, Yang, Jian, Esko, Tonu, Martin, Nicolas W., Westra, Harm-Jan, Shakhbazov, Konstantin, Abdellaoui, Abdel, Agrawal, Arpana, Albrecht, Eva, Alizadeh, Behrooz Z., Amin, Najaf, Bamard, John, Baumeister, Sebastian E., Benke, Kelly S., Bielak, Lawrence F., Boatman, Jeffrey A., Boyle, Patricia A., Davies, Gail, De Leeuw, Christiaan, Eklund, Niina, Evans, Daniel S., Ferhmann, Rudolf, Fischer, Krista, Gieger, Christian, Gjessing, Hakon K., Haegg, Sara, Harris, Jennifer R., Hayward, Caroline, Holzapfel, Christina, Ibrahim-Verbaas, Carla A., Ingelsson, Erik, Jacobsson, Bo, Joshi, Peter K., Jugessur, Astanand, Kaakinen, Marika, Kanoni, Stavroula, Karjalainen, Juha, Kolcic, Ivana, Kristiansson, Kati, Kutalik, Zoltan, Lahti, Jari, Lee, Sang H., Lin, Peng, Lind, Penelope A., Liu, Yongmei, Lohman, Kurt, Loitfelder, Marisa, McMahon, George, Vidal, Pedro Marques, Meirelles, Osorio, Milani, Lili, Myhre, Ronny, Nuotio, Marja-Liisa, Oldmeadow, Christopher J., Petrovic, Katja E., Peyrot, Wouter J., Polasek, Ozren, Quaye, Lydia, Reinmaa, Eva, Rice, John P., Rizzi, Thais S., Schmidt, Helena, Schmidt, Reinhold, Smith, Albert V., Smith, Jennifer A., Tanaka, Toshiko, Terracciano, Antonio, van der Loos, Matthijs J. H. M., Vitart, Veronique, Voelzke, Henry, Wellmann, Juergen, Yu, Lei, Zhao, Wei, Allik, Jueri, Attia, John R., Bandinelli, Stefania, Bastardot, Franois, Beauchamp, Jonathan, Bennett, David A., Berger, Klaus, Bierut, Laura J., Boomsma, Dorret I., Bueltmann, Ute, Campbell, Harry, Chabris, Christopher F., Cherkas, Lynn, Chung, Mina K., Cucca, Francesco, de Andrade, Mariza, De Jager, Philip L., De Neve, Jan-Emmanuel, Deary, Ian J., Dedoussis, George V., Deloukas, Panos, Dimitriou, Maria, Eiriksdottir, Guony, Elderson, Martin F., Eriksson, Johan G., Evans, David M., Faul, Jessica D., Ferrucci, Luigi, Garcia, Melissa E., Groenberg, Henrik, Guonason, Vilmundur, Hall, Per, Harris, Juliette M., Harris, Tamara B., Hastie, Nicholas D., Heath, Andrew C., Hernandez, Dena G., Hoffmann, Wolfgang, Hofman, Adriaan, Holle, Rolf, Holliday, Elizabeth G., Hottenga, Jouke-Jan, Iacono, William G., Illig, Thomas, Jaervelin, Marjo-Riitta, Kaehoenen, Mika, Kaprio, Jaakko, Kirkpatrick, Robert M., Kowgier, Matthew, Latvala, Antti, Launer, Lenore J., Lawlor, Debbie A., Lehtimaeki, Terho, Li, Jingmei, Lichtenstein, Paul, Lichtner, Peter, Liewald, David C., Madden, Pamela A., Magnusson, Patrik K. E., Maekinen, Tomi E., Masala, Marco, McGue, Matt, Metspalu, Andres, Mielck, Andreas, Miller, Michael B., Montgomery, Grant W., Mukherjee, Sutapa, Nyholt, Dale R., Oostra, Ben A., Palmer, Lyle J., Palotie, Aarno, Penninx, Brenda W. J. H., Perola, Markus, Peyser, Patricia A., Preisig, Martin, Raeikkoenen, Katri, Raitakari, Olli T., Realo, Anu, Ring, Susan M., Ripatti, Samuli, Rivadeneira, Fernando, Rudan, Igor, Rustichini, Aldo, Salomaa, Veikko, Sarin, Antti-Pekka, Schlessinger, David, Scott, Rodney J., Snieder, Harold, St Pourcain, Beate, Starr, John M., Sul, Jae Hoon, Surakka, Ida, Svento, Rauli, Teumer, Alexander, Tiemeier, Henning, van Rooij, Frank J. A., Van Wagoner, David R., Vartiainen, Erkki, Viikari, Jorma, Vollenweider, Peter, Vonk, Judith M., Waeber, Gerard, Weir, David R., Wichmann, H. -Erich, Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F., Wright, Alan F., Conley, Dalton, Davey-Smith, George, Franke, Lude, Groenen, Patrick J. F., Hofman, Albert, Johannesson, Magnus, Kardia, Sharon L. R., Krueger, Robert F., Laibson, David, Martin, Nicholas G., Meyer, Michelle N., Posthuma, Danielle, Thurik, A. Roy, Timpson, Nicholas J., Uitterlinden, Andre G., van Duijn, Cornelia M., Visscher, Peter M., Benjamin, Daniel J., Cesarini, David and Koellinger, Philipp D. (2013) GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science, 340 6139: 1467-1471. doi:10.1126/science.1235488

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Author Rietveld, Cornelius A.
Medland, Sarah E.
Derringer, Jaime
Yang, Jian
Esko, Tonu
Martin, Nicolas W.
Westra, Harm-Jan
Shakhbazov, Konstantin
Abdellaoui, Abdel
Agrawal, Arpana
Albrecht, Eva
Alizadeh, Behrooz Z.
Amin, Najaf
Bamard, John
Baumeister, Sebastian E.
Benke, Kelly S.
Bielak, Lawrence F.
Boatman, Jeffrey A.
Boyle, Patricia A.
Davies, Gail
De Leeuw, Christiaan
Eklund, Niina
Evans, Daniel S.
Ferhmann, Rudolf
Fischer, Krista
Gieger, Christian
Gjessing, Hakon K.
Haegg, Sara
Harris, Jennifer R.
Hayward, Caroline
Holzapfel, Christina
Ibrahim-Verbaas, Carla A.
Ingelsson, Erik
Jacobsson, Bo
Joshi, Peter K.
Jugessur, Astanand
Kaakinen, Marika
Kanoni, Stavroula
Karjalainen, Juha
Kolcic, Ivana
Kristiansson, Kati
Kutalik, Zoltan
Lahti, Jari
Lee, Sang H.
Lin, Peng
Lind, Penelope A.
Liu, Yongmei
Lohman, Kurt
Loitfelder, Marisa
McMahon, George
Vidal, Pedro Marques
Meirelles, Osorio
Milani, Lili
Myhre, Ronny
Nuotio, Marja-Liisa
Oldmeadow, Christopher J.
Petrovic, Katja E.
Peyrot, Wouter J.
Polasek, Ozren
Quaye, Lydia
Reinmaa, Eva
Rice, John P.
Rizzi, Thais S.
Schmidt, Helena
Schmidt, Reinhold
Smith, Albert V.
Smith, Jennifer A.
Tanaka, Toshiko
Terracciano, Antonio
van der Loos, Matthijs J. H. M.
Vitart, Veronique
Voelzke, Henry
Wellmann, Juergen
Yu, Lei
Zhao, Wei
Allik, Jueri
Attia, John R.
Bandinelli, Stefania
Bastardot, Franois
Beauchamp, Jonathan
Bennett, David A.
Berger, Klaus
Bierut, Laura J.
Boomsma, Dorret I.
Bueltmann, Ute
Campbell, Harry
Chabris, Christopher F.
Cherkas, Lynn
Chung, Mina K.
Cucca, Francesco
de Andrade, Mariza
De Jager, Philip L.
De Neve, Jan-Emmanuel
Deary, Ian J.
Dedoussis, George V.
Deloukas, Panos
Dimitriou, Maria
Eiriksdottir, Guony
Elderson, Martin F.
Eriksson, Johan G.
Evans, David M.
Faul, Jessica D.
Ferrucci, Luigi
Garcia, Melissa E.
Groenberg, Henrik
Guonason, Vilmundur
Hall, Per
Harris, Juliette M.
Harris, Tamara B.
Hastie, Nicholas D.
Heath, Andrew C.
Hernandez, Dena G.
Hoffmann, Wolfgang
Hofman, Adriaan
Holle, Rolf
Holliday, Elizabeth G.
Hottenga, Jouke-Jan
Iacono, William G.
Illig, Thomas
Jaervelin, Marjo-Riitta
Kaehoenen, Mika
Kaprio, Jaakko
Kirkpatrick, Robert M.
Kowgier, Matthew
Latvala, Antti
Launer, Lenore J.
Lawlor, Debbie A.
Lehtimaeki, Terho
Li, Jingmei
Lichtenstein, Paul
Lichtner, Peter
Liewald, David C.
Madden, Pamela A.
Magnusson, Patrik K. E.
Maekinen, Tomi E.
Masala, Marco
McGue, Matt
Metspalu, Andres
Mielck, Andreas
Miller, Michael B.
Montgomery, Grant W.
Mukherjee, Sutapa
Nyholt, Dale R.
Oostra, Ben A.
Palmer, Lyle J.
Palotie, Aarno
Penninx, Brenda W. J. H.
Perola, Markus
Peyser, Patricia A.
Preisig, Martin
Raeikkoenen, Katri
Raitakari, Olli T.
Realo, Anu
Ring, Susan M.
Ripatti, Samuli
Rivadeneira, Fernando
Rudan, Igor
Rustichini, Aldo
Salomaa, Veikko
Sarin, Antti-Pekka
Schlessinger, David
Scott, Rodney J.
Snieder, Harold
St Pourcain, Beate
Starr, John M.
Sul, Jae Hoon
Surakka, Ida
Svento, Rauli
Teumer, Alexander
Tiemeier, Henning
van Rooij, Frank J. A.
Van Wagoner, David R.
Vartiainen, Erkki
Viikari, Jorma
Vollenweider, Peter
Vonk, Judith M.
Waeber, Gerard
Weir, David R.
Wichmann, H. -Erich
Widen, Elisabeth
Willemsen, Gonneke
Wilson, James F.
Wright, Alan F.
Conley, Dalton
Davey-Smith, George
Franke, Lude
Groenen, Patrick J. F.
Hofman, Albert
Johannesson, Magnus
Kardia, Sharon L. R.
Krueger, Robert F.
Laibson, David
Martin, Nicholas G.
Meyer, Michelle N.
Posthuma, Danielle
Thurik, A. Roy
Timpson, Nicholas J.
Uitterlinden, Andre G.
van Duijn, Cornelia M.
Visscher, Peter M.
Benjamin, Daniel J.
Cesarini, David
Koellinger, Philipp D.
Title GWAS of 126,559 individuals identifies genetic variants associated with educational attainment
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
1095-9203
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1126/science.1235488
Open Access Status File (Author Post-print)
Volume 340
Issue 6139
Start page 1467
End page 1471
Total pages 5
Place of publication Washington, DC, United States
Publisher American Association for the Advancement of Science
Collection year 2014
Language eng
Formatted abstract
A genome-wide association study (GWAS) of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490. Three independent single-nucleotide polymorphisms (SNPs) are genome-wide significant (rs9320913, rs11584700, rs4851266), and all three replicate. Estimated effects sizes are small (coefficient of determination R2≈ 0.02%), approximately 1 month of schooling per allele. A linear polygenic score from all measured SNPs accounts for ≈2% of the variance in both educational attainment and cognitive function. Genes in the region of the loci have previously been associated with health, cognitive, and central nervous system phenotypes, and bioinformatics analyses suggest the involvement of the anterior caudate nucleus. These findings provide promising candidate SNPs for follow-up work, and our effect size estimates can anchor power analyses in social-science genetics.
Keyword Environment
Preferences
Loci
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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