The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?

Wright, Olivia R. L., Hickman, Ingrid J., Petchey, William G., Sullivan, Clair M., Ong, Cynthia, Rose, Felicity J., Ng, Choaping, Prins, Johannes B., Whitehead, Jonathan P. and O'Moore-Sullivan, Trisha M. (2013) The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?. Canadian Journal of Physiology and Pharmacology, 91 6: 496-501. doi:10.1139/cjpp-2012-0436

Author Wright, Olivia R. L.
Hickman, Ingrid J.
Petchey, William G.
Sullivan, Clair M.
Ong, Cynthia
Rose, Felicity J.
Ng, Choaping
Prins, Johannes B.
Whitehead, Jonathan P.
O'Moore-Sullivan, Trisha M.
Title The effect of 25-hydroxyvitamin D on insulin sensitivity in obesity: is it mediated via adiponectin?
Journal name Canadian Journal of Physiology and Pharmacology   Check publisher's open access policy
ISSN 0008-4212
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1139/cjpp-2012-0436
Open Access Status
Volume 91
Issue 6
Start page 496
End page 501
Total pages 6
Place of publication Ottawa, ON, Canada
Publisher N R C Research Press
Collection year 2014
Language eng
Formatted abstract
There has been substantial recent interest in using vitamin D to improve insulin sensitivity and preventing/ delaying diabetes in those at risk. There is little consensus on the physiological mechanisms and whether the association is direct or indirect through enhanced production of insulin-sensitising chemicals, including adiponectin. We examined cross-sectional associations between serum 25-hydroxyvitamin D (25(OH)D) and insulin sensitivity (Matsuda index), parathyroid hormone (PTH), waist circumference, body mass index (BMI), triglycerides (TG), total and high molecular weight (HMW) adiponectin, HMW: total adiponectin ratio (HMW: total adiponectin), and total cholesterol: HDL cholesterol ratio (TC:HDL cholesterol) in 137 Caucasian adults of mean age 43.3 ± 8.3 years and BMI 38.8 ± 6.9 kg/m2. Total adiponectin (standardised β = 0.446; p < 0.001), waist circumference (standardised β =-0.216; p < 0.05), BMI (standardised β =-0.212; p < 0.05), and age (standardised β =-0.298; p < 0.001) were independently associated with insulin sensitivity. Serum 25(OH)D (standardised β = 0.114; p = 0.164) was not associated with insulin sensitivity, total or HMW adiponectin, HMW: total adiponectin, or lipids. Our results provide the novel finding that 25(OH)D is not associated withHMWadiponectin orHMW: total adiponectin in nondiabetic, obese adults and support the lack of association between 25(OH)D and lipids noted by others in similar groups of patients.
Keyword Obesity
Vitamin D
Insulin sensitivity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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