Cough sound analysis can rapidly diagnose childhood pneumonia

Abeyratne, Udantha R., Swarnkar, Vinayak, Setyati, Amaliya and Triasih, Rina (2013) Cough sound analysis can rapidly diagnose childhood pneumonia. Annals of Biomedical Engineering, 41 11: 2448-2462. doi:10.1007/s10439-013-0836-0

Author Abeyratne, Udantha R.
Swarnkar, Vinayak
Setyati, Amaliya
Triasih, Rina
Title Cough sound analysis can rapidly diagnose childhood pneumonia
Journal name Annals of Biomedical Engineering   Check publisher's open access policy
ISSN 0090-6964
Publication date 2013-06-07
Year available 2013
Sub-type Article (original research)
DOI 10.1007/s10439-013-0836-0
Open Access Status
Volume 41
Issue 11
Start page 2448
End page 2462
Total pages 15
Place of publication New York, NY, United States
Publisher Springer
Collection year 2014
Language eng
Abstract Pneumonia annually kills over 1,800,000 children throughout the world. The vast majority of these deaths occur in resource poor regions such as the sub-Saharan Africa and remote Asia. Prompt diagnosis and proper treatment are essential to prevent these unnecessary deaths. The reliable diagnosis of childhood pneumonia in remote regions is fraught with difficulties arising from the lack of field-deployable imaging and laboratory facilities as well as the scarcity of trained community healthcare workers. In this paper, we present a pioneering class of technology addressing both of these problems. Our approach is centred on the automated analysis of cough and respiratory sounds, collected via microphones that do not require physical contact with subjects. Cough is a cardinal symptom of pneumonia but the current clinical routines used in remote settings do not make use of coughs beyond noting its existence as a screening-in criterion. We hypothesized that cough carries vital information to diagnose pneumonia, and developed mathematical features and a pattern classifier system suited for the task. We collected cough sounds from 91 patients suspected of acute respiratory illness such as pneumonia, bronchiolitis and asthma. Non-contact microphones kept by the patient's bedside were used for data acquisition. We extracted features such as non-Gaussianity and Mel Cepstra from cough sounds and used them to train a Logistic Regression classifier. We used the clinical diagnosis provided by the paediatric respiratory clinician as the gold standard to train and validate our classifier. The methods proposed in this paper could separate pneumonia from other diseases at a sensitivity and specificity of 94 and 75% respectively, based on parameters extracted from cough sounds alone. The inclusion of other simple measurements such as the presence of fever further increased the performance. These results show that cough sounds indeed carry critical information on the lower respiratory tract, and can be used to diagnose pneumonia. The performance of our method is far superior to those of existing WHO clinical algorithms for resource-poor regions. To the best of our knowledge, this is the first attempt in the world to diagnose pneumonia in humans using cough sound analysis. Our method has the potential to revolutionize the management of childhood pneumonia in remote regions of the world.
Keyword Automated cough analysis
Childhood cough
Q-Index Code C1
Q-Index Status Confirmed Code
Funding Body Bill & Melinda Gates Foundation
Grant ID OPP1008199 GCE
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Information Technology and Electrical Engineering Publications
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 18 Jul 2013, 16:37:06 EST by Mr Vinayak Swarnkar on behalf of School of Information Technol and Elec Engineering