DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.

Pavey, Sandra, Spoerri, Loredana, Haass, Nikolas K. and Gabrielli, Brian (2013) DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.. Pigment Cell and Melanoma Research, 26 6: 805-816. doi:10.1111/pcmr.12136


Author Pavey, Sandra
Spoerri, Loredana
Haass, Nikolas K.
Gabrielli, Brian
Title DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.
Journal name Pigment Cell and Melanoma Research   Check publisher's open access policy
ISSN 1755-1471
1755-148X
Publication date 2013-11
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/pcmr.12136
Volume 26
Issue 6
Start page 805
End page 816
Total pages 12
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell Publishing
Collection year 2014
Language eng
Formatted abstract
The ultraviolet radiation (UVR) component of sunlight is the major environmental risk factor for melanoma, producing DNA lesions that can be mutagenic if not repaired. The high level of mutations in melanomas that have the signature of UVR-induced damage indicates that the normal mechanisms that detect and repair this damage must be defective in this system. With the exception of melanoma-prone heritable syndromes which have mutations of repair genes, there is little evidence for somatic mutation of known repair genes. Cell cycle checkpoint controls are tightly associated with repair mechanisms, arresting cells to allow for repair before continuing through the cell cycle. Checkpoint signaling components also regulate the repair mechanisms. Defects in checkpoint mechanisms have been identified in melanomas and are likely to be responsible for increased mutation load in melanoma. Loss of the checkpoint responses may also provide an opportunity to target melanomas using a synthetic lethal approach to identify and inhibit mechanisms that compensate for the defective checkpoints.
Keyword Cell cycle checkpoint
DNA damage
DNA repair
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 16 Jul 2013, 11:21:42 EST by Dr Sandra Pavey on behalf of UQ Diamantina Institute