Defective decatenation checkpoint function is a common feature of melanoma

Brooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013) Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 1: 150-158. doi:10.1038/jid.2013.264


Author Brooks, Kelly
Chia, Kee Ming
Spoerri, Loredana
Mukhopadhyay, Pamela
Wigan, Matthew
Stark, Mitchell
Pavey, Sandra
Gabrielli, Brian
Title Defective decatenation checkpoint function is a common feature of melanoma
Journal name Journal of Investigative Dermatology   Check publisher's open access policy
ISSN 0022-202X
1523-1747
Publication date 2013-06-13
Year available 2013
Sub-type Article (original research)
DOI 10.1038/jid.2013.264
Volume 134
Issue 1
Start page 150
End page 158
Total pages 9
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2014
Language eng
Formatted abstract
A hallmark of cancer is genomic instability that is considered to provide the adaptive capacity of cancers to thrive under conditions in which the normal precursors would not survive. Recent genomic analysis has revealed a very high degree of genomic instability in melanomas, although the mechanism by which this instability arises is not known. Here we report that a high proportion (68%) of melanoma cell lines are either partially (40%) or severely (28%) compromised for the G2 phase decatenation checkpoint that normally functions to ensure that the sister chromatids are able to separate correctly during mitosis. The consequence of this loss of checkpoint function is a severely reduced ability to partition the replicated genome in mitosis and thereby increase genomic instability. We also demonstrate that decatenation is dependent on both TopoIIα and β isoforms. The high incidence of decatenation checkpoint defect is likely to be a major contributor to the high level of genomic instability found in melanomas.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 16 Jul 2013, 11:17:24 EST by Dr Sandra Pavey on behalf of UQ Diamantina Institute