Identification of single nucleotide polymorphisms in genes involved in digestive and metabolic processes associated with feed efficiency and performance traits in beef cattle

Abo-Ismail, M. K., Kelly, M. J., Squires, E. J., Swanson, K. C., Bauck, S. and Miller, S. P. (2013) Identification of single nucleotide polymorphisms in genes involved in digestive and metabolic processes associated with feed efficiency and performance traits in beef cattle. Journal of Animal Science, 91 6: 2512-2529. doi:10.2527/jas2012-5756


Author Abo-Ismail, M. K.
Kelly, M. J.
Squires, E. J.
Swanson, K. C.
Bauck, S.
Miller, S. P.
Title Identification of single nucleotide polymorphisms in genes involved in digestive and metabolic processes associated with feed efficiency and performance traits in beef cattle
Journal name Journal of Animal Science   Check publisher's open access policy
ISSN 0021-8812
1525-3163
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.2527/jas2012-5756
Volume 91
Issue 6
Start page 2512
End page 2529
Total pages 18
Place of publication Savoy, IL, United States
Publisher American Society of Animal Science
Collection year 2014
Language eng
Formatted abstract
Discovery of genetic mutations that have a significant association with economically important traits would benefit beef cattle breeders. Objectives were to identify with an in silico approach new SNP in 8 genes involved in digestive function and metabolic processes and to examine the associations between the identified SNP and feed efficiency and performance traits. The association between SNP and daily DMI, ADG, midpoint metabolic weight (MMWT), residual feed intake (RFI),
and feed conversion ratio (FCR; the ratio of average daily DMI to ADG) was tested in discovery and validation populations using a univariate mixed-inheritance animal model fitted in ASReml. Substitution effect of the T allele of SNP rs41256901 in protease, serine, 2 (trypsin 2; PRSS2) was associated with FCR (–0.293 ± 0.08 kg DMI kg –1 BW gain; P < 0.001) and RFI (–0.199 ± 0.08 kg; P < 0.01) and although not significant in the validation population, the phase of association remained. In the cholecystokinin B receptor (CCKBR) gene, genotypes in rs42670351 were associated with RFI (P< 0.05) whereas genotypes in rs42670352 were associated with RFI (P=0.002) and DMI (P< 0.05). Substitution of the G allele in rs42670352 was associated with DMI (–0.236 ±0.12kg;P= 0.055) and RFI (–0.175 ± 0.09 kg; P= 0.05).Substitution of the G allele of SNP rs42670353 was associated with ADG (0.043 ± 0.02 kg/d; P< 0.01) and FCR (0.114 ± 0.05 kg BW gain kg –1 DMI; P< 0.05). In the validation dataset, SNP rs42670352 in gene CCKBR was significant for RFI and DMI and had the same phase of associations; SNP rs42670353 was significantly associated with FCR with same phase of association and the C allele in SNP rs42670351 was validated as decreasing DMI, RFI, and FCR. Substituting the G allele of SNP rs42670352 in CCKBR2 was associated with decreasing DMI and RFI in the validation study. New SNP were reported in genes PRSS2 and CCKBR,
being associated with feed efficiency and performance traits in beef cattle. The association between these SNP with fertility, carcass, and meat quality traits must still be tested.
Keyword Beef cattle
Candidate genes
Feed efficiency
Single nucleotide polymorphism
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
 
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