Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height

Utsunomiya, Yuri T., do Carmo, Adriana S., Carvalheiro, Roberto, Neves, Haroldo H. R., Matos, Marcia C., Zavarez, Ludmilla B., O'Brien, Ana M. Perez, Soelkner, Johann, McEwan, John C., Cole, John B., Van Tassell, Curtis P., Schenkel, Flavio S., da Silva, Marcos V. G. B., Porto Neto, Laercio R., Sonstegard, Tad S. and Garcia, Jose F. (2013) Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height. BMC Genetics, 14 52.1-52.12. doi:10.1186/1471-2156-14-52


Author Utsunomiya, Yuri T.
do Carmo, Adriana S.
Carvalheiro, Roberto
Neves, Haroldo H. R.
Matos, Marcia C.
Zavarez, Ludmilla B.
O'Brien, Ana M. Perez
Soelkner, Johann
McEwan, John C.
Cole, John B.
Van Tassell, Curtis P.
Schenkel, Flavio S.
da Silva, Marcos V. G. B.
Porto Neto, Laercio R.
Sonstegard, Tad S.
Garcia, Jose F.
Title Genome-wide association study for birth weight in Nellore cattle points to previously described orthologous genes affecting human and bovine height
Journal name BMC Genetics   Check publisher's open access policy
ISSN 1471-2156
Publication date 2013-06
Sub-type Article (original research)
DOI 10.1186/1471-2156-14-52
Open Access Status DOI
Volume 14
Start page 52.1
End page 52.12
Total pages 12
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2014
Language eng
Formatted abstract
Background: Birth weight (BW) is an economically important trait in beef cattle, and is associated with growth- and stature-related traits and calving difficulty. One region of the cattle genome, located on Bos primigenius taurus chromosome 14 (BTA14), has been previously shown to be associated with stature by multiple independent studies, and contains orthologous genes affecting human height. A genome-wide association study (GWAS) for BW in Brazilian Nellore cattle (Bos primigenius indicus) was performed using estimated breeding values (EBVs) of 654 progeny-tested bulls genotyped for over 777,000 single nucleotide polymorphisms (SNPs).

Results: The most significant SNP (rs133012258, PGC = 1.34 × 10-9), located at BTA14:25376827, explained 4.62% of the variance in BW EBVs. The surrounding 1 Mb region presented high identity with human, pig and mouse autosomes 8, 4 and 4, respectively, and contains the orthologous height genes PLAG1, CHCHD7, MOS, RPS20, LYN, RDHE2 (SDR16C5) and PENK. The region also overlapped 28 quantitative trait loci (QTLs) previously reported in literature by linkage mapping studies in cattle, including QTLs for birth weight, mature height, carcass weight, stature, pre-weaning average daily gain, calving ease, and gestation length.

Conclusions: This study presents the first GWAS applying a high-density SNP panel to identify putative chromosome regions affecting birth weight in Nellore cattle. These results suggest that the QTLs on BTA14 associated with body size in taurine cattle (Bos primigenius taurus) also affect birth weight and size in zebu cattle (Bos primigenius indicus).
Keyword GWAS
Birth weight
Bos primigenius indicus
Nellore cattle
Stature
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
 
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