Joseph Rudinger memorial lecture: discovery and applications of cyclotides

Craik, David J. (2013) Joseph Rudinger memorial lecture: discovery and applications of cyclotides. Journal of Peptide Science, 19 7: 393-407. doi:10.1002/psc.2523


Author Craik, David J.
Title Joseph Rudinger memorial lecture: discovery and applications of cyclotides
Journal name Journal of Peptide Science   Check publisher's open access policy
ISSN 1075-2617
1099-1387
Publication date 2013-07
Sub-type Article (original research)
DOI 10.1002/psc.2523
Volume 19
Issue 7
Start page 393
End page 407
Total pages 15
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2014
Language eng
Abstract Cyclotides are plant-derived peptides of approximately 30 amino acids that have the characteristic structural features of a head-to-tail cyclized backbone and a cystine knot arrangement of their three conserved disulfide bonds. This article gives a personal account of the discovery of cyclotides, their characterization and their applications, based on work carried out in my laboratory over the last 20years. It describes some of the background to their discovery and focuses on how their unique structural features lead to exceptional stability. This stability and their amenability to chemical synthesis have made it possible to use cyclotides as templates in protein engineering and drug design applications. These applications complement the interest in cyclotides deriving from their unique structures and natural function as host defense molecules.
Keyword Cyclic peptides
Cyclotides
Drug design
Structure
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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