Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis.

Khalesi, Mohammad, Whiteman, David C., Doi, Suhail A. R., Clark, Justin, Kimlin, Michael G. and Neale, Rachel E. (2013) Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis.. Cancer Epidemiology Biomarker Prevention, 22 9: 1483-1489. doi:10.1158/1055-9965.EPI-13-0424

Author Khalesi, Mohammad
Whiteman, David C.
Doi, Suhail A. R.
Clark, Justin
Kimlin, Michael G.
Neale, Rachel E.
Title Cutaneous markers of photo-damage and risk of basal cell carcinoma of the skin: A meta-analysis.
Journal name Cancer Epidemiology Biomarker Prevention   Check publisher's open access policy
ISSN 1055-9965
Publication date 2013
Year available 2013
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-13-0424
Open Access Status
Volume 22
Issue 9
Start page 1483
End page 1489
Total pages 4
Place of publication Philadelphia, PA United States
Publisher American Association for Cancer Research
Collection year 2014
Language eng
Formatted abstract
Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted quantitative assessment of the association between histologically confirmed BCC and actinic keratoses, solar elastosis, solar lentigines, or telangiectasia. Seven eligible studies were identified and summary odds ratios (ORs) were calculated using both random and quality effects models. Having more than ten actinic keratoses was most strongly associated with BCC, conferring up to a fivefold increase in risk (OR: 4.97; 95% CI: 3.26-7.58). Other factors, including solar elastosis, solar lentigines, and telangiectasia had weaker but positive associations with BCC with ORs around 1.5. Markers of chronic photo-damage are positively associated with BCC. The presence of actinic keratoses was the most strongly associated with BCC of the markers examined. This work highlights the relatively modest association between markers of chronic ultraviolet exposure and BCC.
Keyword Basal cell
Cutaneous Markers
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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Created: Thu, 11 Jul 2013, 09:17:39 EST by Dr Suhail Doi on behalf of School of Public Health