Cyclotide biosynthesis

Craik, David J. and Malik, Uru (2013) Cyclotide biosynthesis. Current Opinion In Chemical Biology, 17 4: 546-554. doi:10.1016/j.cbpa.2013.05.033

Author Craik, David J.
Malik, Uru
Title Cyclotide biosynthesis
Journal name Current Opinion In Chemical Biology   Check publisher's open access policy
ISSN 1367-5931
Publication date 2013-08-04
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.cbpa.2013.05.033
Volume 17
Issue 4
Start page 546
End page 554
Total pages 9
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2014
Language eng
Abstract Cyclotides are bioactive macrocyclic peptides from plants that are characterized by their exceptional stability and potential applications as protein engineering or drug design frameworks. Their stability arises from their unique cyclic cystine knot structure, which combines a head-to-tail cyclic peptide backbone with three conserved disulfide bonds having a knotted topology. Cyclotides are ribosomally synthesized by plants and expressed in a wide range of tissues, including leaves, flowers, stems and roots. Here we describe recent studies that have examined the biosynthesis of cyclotides and in particular the mechanism associated with post-translational backbone cyclization.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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Created: Mon, 08 Jul 2013, 15:20:05 EST by Susan Allen on behalf of Institute for Molecular Bioscience