Stroke prevention in atrial fibrillation: an update on current management strategies

Hall, T., Stanton, T., Wang, W. Y. S. and Ng, A. C. T. (2013) Stroke prevention in atrial fibrillation: an update on current management strategies. Panminerva Medica, 55 1: 43-58.

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Author Hall, T.
Stanton, T.
Wang, W. Y. S.
Ng, A. C. T.
Title Stroke prevention in atrial fibrillation: an update on current management strategies
Journal name Panminerva Medica   Check publisher's open access policy
ISSN 0031-0808
Publication date 2013-03
Year available 2013
Sub-type Article (original research)
Volume 55
Issue 1
Start page 43
End page 58
Total pages 16
Place of publication Turin, Italy
Publisher Edizioni Minerva Medica
Collection year 2014
Language eng
Formatted abstract
Stroke attributed to atrial fibrillation (AF) confers significant morbidity and mortality. In the past, warfarin has been the only successful stroke prevention agent available. However, it is often underutilized due to its well-known limitations, leaving many patients without adequate stroke protection. The last decade has seen significant strides forward in the field of anticoagulation for AF. The development of several novel oral anticoagulants that have superior efficacy, improved safety profile and fixed doses without the need for regular monitoring make them favorable as viable alternatives to warfarin. Improved risk scoring systems for both thrombembolism and bleeding have also allowed clinicians to better target patients most likely to benefit from these new therapies. In addition, non-pharmacological approaches to stroke prevention such as left atrial appendage exclusion devices may be useful in patients whom anticoagulation therapy is contraindicated. These new pharmacological and non-pharmacological options for stroke prevention in AF permit clinicians to tailor their management of patients according to individual needs and characteristics. The present review aims to outline the latest up-to-date management of AF in stroke prevention.
Keyword Atrial fibrillation
Appendage transcatheter occlusion
High-risk patients
Clinical classification schemes
Randomized controlled-trial
Normalized ratio control
Factor Xa inhibitor
Euro heart survey
Re-Ly trial
Antithrombotic therapy
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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