A new temporal window for inducing depressant associative plasticity in human primary motor cortex

Schabrun, S. M., Weise, D., Ridding, M. C. and Classen, J. (2013) A new temporal window for inducing depressant associative plasticity in human primary motor cortex. Clinical Neurophysiology, 124 6: 1196-1203. doi:10.1016/j.clinph.2013.01.004


Author Schabrun, S. M.
Weise, D.
Ridding, M. C.
Classen, J.
Title A new temporal window for inducing depressant associative plasticity in human primary motor cortex
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1388-2457
1872-8952
Publication date 2013-06
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.clinph.2013.01.004
Open Access Status
Volume 124
Issue 6
Start page 1196
End page 1203
Total pages 8
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Collection year 2014
Language eng
Formatted abstract
Objective
Spike-timing dependent plasticity (STDP) usually refers to synaptic plasticity induced by near-synchronous activation of neuronal input and neuronal firing. However, some models of STDP predict effects that deviate from this tight temporal synchrony. We aimed to characterise the induction of STDP using paired associative stimulation (PAS) when the pre-synaptic input arrives in primary motor cortex (M1) at (i) intermediate intervals (50–80 ms; PAS50,..PAS80) before the post-synaptic neuron is activated and (ii) long intervals (100–450 ms; PAS−100,..PAS−450) after the post-synaptic neuron is activated. PAS at near-synchronicity (PAS25) was applied for comparison.

Methods
To characterise the physiological effects of the different PAS protocols, we examined short- and long-interval intra-cortical inhibition; intra-cortical facilitation and short- and long-latency afferent inhibition, in addition to recording MEPs in 45 healthy individuals.

Results
MEP amplitude was reduced at PAS intervals between −250 and −450 ms, increased with PAS25, and unaltered at the remaining intervals. There was no change in intra-cortical inhibitory or facilitatory circuits following any PAS protocol.

Conclusions
These findings provide evidence of a previously unreported temporal window in which PAS induces a depression of corticospinal excitability in human M1.

Significance
Establishing new temporal rules for STDP broadens its applicability for therapeutic usage in future.
Keyword Human
Paired associative stimulation (PAS)
Primary motor cortex
Spike-timing dependent plasticity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Health and Rehabilitation Sciences Publications
 
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