Mycobacterium abscessus isolated from municipal water - a potential source of human infection

Thomson, Rachel, Tolson, Carla, Sidjabat, Hanna, Huygens, Flavia and Hargreaves, Megan (2013) Mycobacterium abscessus isolated from municipal water - a potential source of human infection. Bmc Infectious Diseases, 13 241.1-241.7. doi:10.1186/1471-2334-13-241

Author Thomson, Rachel
Tolson, Carla
Sidjabat, Hanna
Huygens, Flavia
Hargreaves, Megan
Title Mycobacterium abscessus isolated from municipal water - a potential source of human infection
Journal name Bmc Infectious Diseases   Check publisher's open access policy
ISSN 1471-2334
Publication date 2013-05
Sub-type Article (original research)
DOI 10.1186/1471-2334-13-241
Open Access Status DOI
Volume 13
Start page 241.1
End page 241.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central Ltd
Collection year 2014
Language eng
Formatted abstract
Background: Mycobacterium abscessus is a rapidly growing mycobacterium responsible for progressive pulmonary disease, soft tissue and wound infections. The incidence of disease due to M. abscessus has been increasing in Queensland. In a study of Brisbane drinking water, M. abscessus was isolated from ten different locations.The aim of this study was to compare genotypically the M. abscessus isolates obtained from water to those obtained from human clinical specimens.

Between 2007 and 2009, eleven isolates confirmed as M. abscessus were recovered from potable water, one strain was isolated from a rainwater tank and another from a swimming pool and two from domestic taps. Seventy-four clinical isolates referred during the same time period were available for comparison using rep-PCR strain typing (Diversilab).

Results: The drinking water isolates formed two clusters with ≥97% genetic similarity (Water patterns 1 and 2). The tankwater isolate (WP4), one municipal water isolate (WP3) and the pool isolate (WP5) were distinctly different. Patient isolates formed clusters with all of the water isolates except for WP3. Further patient isolates were unrelated to the water isolates.

The high degree of similarity between strains of M. abscessus from potable water and strains causing infection in humans from the same geographical area, strengthens the possibility that drinking water may be the source of infection in these patients.
Keyword Nontuberculous Mycobacteria
Distribution systems
Nosocomial Outbreaks
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 241

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 20 times in Scopus Article | Citations
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Created: Sun, 07 Jul 2013, 00:13:01 EST by System User on behalf of UQ Centre for Clinical Research