Brown adipose tissue in adult humans: a metabolic renaissance

Lee, Paul, Swarbrick, Michael M. and Ho, Ken K. Y. (2013) Brown adipose tissue in adult humans: a metabolic renaissance. Endocrine Reviews, 34 3: 413-438. doi:10.1210/er.2012-1081


Author Lee, Paul
Swarbrick, Michael M.
Ho, Ken K. Y.
Title Brown adipose tissue in adult humans: a metabolic renaissance
Journal name Endocrine Reviews   Check publisher's open access policy
ISSN 0163-769X
1945-7189
Publication date 2013-06-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1210/er.2012-1081
Volume 34
Issue 3
Start page 413
End page 438
Total pages 26
Place of publication Chevy Chase, MD, United States
Publisher The Endocrine Society
Collection year 2014
Language eng
Abstract Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in animals, conferring protection against diet-induced obesity and hypothermia through the action of uncoupling protein 1 (UCP1). Recent metabolic imaging studies using positron emission tomography computerized tomography (PET-CT) scanning have serendipitously revealed significant depots of BAT in the cervical-supraclavicular regions, demonstrating persistence of BAT beyond infancy. Subsequent cold-stimulated PET-CT studies and direct histological examination of adipose tissues have demonstrated that BAT is highly prevalent in adult humans. BAT activity correlates positively with increment of energy expenditure during cold exposure and negatively with age, body mass index, and fasting glycemia, suggesting regulatory links between BAT, cold-induced thermogenesis, and energy metabolism. Human BAT tissue biopsies express UCP1 and harbor inducible precursors that differentiate into UCP1-expressing adipocytes in vitro. These recent discoveries represent a metabolic renaissance for human adipose biology, overturning previous belief that BAT had no relevance in adult humans. They also have implications for the understanding of the pathogenesis and treatment of obesity and its metabolic sequelae.
Keyword Body-mass index
Uncoupling protein thermogenin
Diet induced thermogenesis
Activated receptor gamma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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