Testing the activitystat hypothesis: a randomised controlled trial protocol

Gomersall, Sjaan, Maher, Carol, Norton, Kevin, Dollman, Jim, Tomkinson, Grant, Esterman, Adrian, English, Coralie, Lewis, Nicole and Olds, Tim (2012) Testing the activitystat hypothesis: a randomised controlled trial protocol. BMC Public Health, 12 851.1-851.10. doi:10.1186/1471-2458-12-851

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Author Gomersall, Sjaan
Maher, Carol
Norton, Kevin
Dollman, Jim
Tomkinson, Grant
Esterman, Adrian
English, Coralie
Lewis, Nicole
Olds, Tim
Title Testing the activitystat hypothesis: a randomised controlled trial protocol
Journal name BMC Public Health   Check publisher's open access policy
ISSN 1471-2458
Publication date 2012-10-01
Sub-type Article (original research)
DOI 10.1186/1471-2458-12-851
Open Access Status DOI
Volume 12
Start page 851.1
End page 851.10
Total pages 10
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2013
Language eng
Formatted abstract
Background: The activitystat hypothesis proposes that when physical activity or energy expenditure is increased or decreased in one domain, there will be a compensatory change in another domain to maintain an overall, stable level of physical activity or energy expenditure. To date, there has been no experimental study primarily designed to test the activitystat hypothesis in adults. The aim of this trial is to determine the effect of two different imposed exercise loads on total daily energy expenditure and physical activity levels.
Methods: This study will be a randomised, multi-arm, parallel controlled trial. Insufficiently active adults (as determined by the Active Australia survey) aged 18–60 years old will be recruited for this study (n=146). Participants must also satisfy the Sports Medicine Australia Pre-Exercise Screening System and must weigh less than 150 kg. Participants will be randomly assigned to one of three groups using a computer-generated allocation sequence. Participants in the Moderate exercise group will receive an additional 150 minutes of moderate to vigorous physical activity per week for six weeks, and those in the Extensive exercise group will receive an additional 300 minutes of moderate to vigorous physical activity per week for six weeks. Exercise targets will be accumulated through both group and individual exercise sessions monitored by heart rate telemetry. Control participants will not be given any instructions regarding lifestyle. The primary outcome measures are activity energy expenditure (doubly labeled water) and physical activity (accelerometry). Secondary measures will include resting metabolic rate via indirect calorimetry, use of time, maximal oxygen consumption and several anthropometric and physiological measures. Outcome measures will be conducted at baseline (zero weeks), mid- and end-intervention (three and six weeks) with three (12 weeks) and six month (24 week) follow-up. All assessors will be blinded to group allocation.
Discussion: This protocol has been specifically designed to test the activitystat hypothesis while taking into account the key conceptual and methodological considerations of testing a biologically regulated homeostatic feedback loop. Results of this study will be an important addition to the growing literature and debate concerning the possible existence of an activitystat.
Trial registration: Australian New Zealand Clinical Trials Registry ACTRN12610000248066
Keyword Protocol
Randomised controlled trial
Physical activity
Activitystat
References Article # 851
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Human Movement and Nutrition Sciences Publications
 
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Created: Wed, 03 Jul 2013, 20:11:20 EST by Sjaan Gomersall on behalf of School of Human Movement and Nutrition Sciences