Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties

Dulla, Balakrishna, Kirla, Krishna Tulasi, Rathore, Vandana, Deora, Girdhar Singh, Kavela, Sridhar, Maddika, Subbareddy, Chatti, Kiranam, Reiser, Oliver, Iqbal, Javed and Pal, Manojit (2013) Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties. Organic and Biomolecular Chemistry, 11 19: 3103-3107. doi:10.1039/c3ob40217g


Author Dulla, Balakrishna
Kirla, Krishna Tulasi
Rathore, Vandana
Deora, Girdhar Singh
Kavela, Sridhar
Maddika, Subbareddy
Chatti, Kiranam
Reiser, Oliver
Iqbal, Javed
Pal, Manojit
Title Synthesis and evaluation of 3-amino/guanidine substituted phenyl oxazoles as a novel class of LSD1 inhibitors with anti-proliferative properties
Journal name Organic and Biomolecular Chemistry   Check publisher's open access policy
ISSN 1477-0520
1477-0539
Publication date 2013-05-21
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c3ob40217g
Open Access Status Not Open Access
Volume 11
Issue 19
Start page 3103
End page 3107
Total pages 5
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2014
Language eng
Formatted abstract
A series of functionalized phenyl oxazole derivatives was designed, synthesized and screened in vitro for their activities against LSD1 and for effects on viability of cervical and breast cancer cells, and in vivo for effects using zebrafish embryos. These compounds are likely to act via multiple epigenetic mechanisms specific to cancer cells including LSD1 inhibition.
Keyword Histone demethylase LSD1
Analogs
Receptor
Reexpression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
 
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