In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity

Ohlyan, Renu, Kandale, Ajit, Deora, Girdhar Singh, Rathore, Vandana and Chahal, Jagbir (2013) In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity. Medicinal Chemistry Research, 22 3: 1365-1370. doi:10.1007/s00044-012-0122-y


Author Ohlyan, Renu
Kandale, Ajit
Deora, Girdhar Singh
Rathore, Vandana
Chahal, Jagbir
Title In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity
Formatted title
In vitro screening of dry fruit extracts of Piper attenuatum for antioxidant and anticancer activity
Journal name Medicinal Chemistry Research   Check publisher's open access policy
ISSN 1054-2523
1554-8120
Publication date 2013-03-01
Year available 2012
Sub-type Article (original research)
DOI 10.1007/s00044-012-0122-y
Volume 22
Issue 3
Start page 1365
End page 1370
Total pages 6
Place of publication Cambridge, MA, United States
Publisher Birkhaeuser Boston
Collection year 2014
Language eng
Formatted abstract
Indian traditional medicinal plant Piper attenuatum (Buch-Ham) has been investigated for its antioxidant and anticancer activity. Three extracts were prepared using ethyl acetate, ethanol and methanol. In vitro antioxidant activity was performed by ABTS {2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)} free radical scavenging method. All three extracts reduced the free radicals produced by ABTS in a concentration-dependent manner which could be compared to the standard (gallic acid). Invitro anticancer activity of all extracts was carried out by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay method against MCF7 (Michigan Cancer Foundation-7) cell lines. None of the extract showed anticancer activity when compared with the standard (mitomycin C) indicating that P. attenuatum is deprived of antiproliferative or cytotoxic components.
Keyword Piper attenuatum
Anticancer
MCF7 cell lines
Antioxidant
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Published online 15 June 2012

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 2 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 01 Jul 2013, 22:53:18 EST by System User on behalf of School of Pharmacy