Has the time come for routine trimethoprim-sulfamethoxazole prophylaxis in patients taking biologic therapies?

Bodro, Marta and Paterson, David L. (2013) Has the time come for routine trimethoprim-sulfamethoxazole prophylaxis in patients taking biologic therapies?. Clinical Infectious Diseases, 56 11: 1621-1628. doi:10.1093/cid/cit071


Author Bodro, Marta
Paterson, David L.
Title Has the time come for routine trimethoprim-sulfamethoxazole prophylaxis in patients taking biologic therapies?
Journal name Clinical Infectious Diseases   Check publisher's open access policy
ISSN 1058-4838
1537-6591
Publication date 2013-06-01
Sub-type Article (original research)
DOI 10.1093/cid/cit071
Volume 56
Issue 11
Start page 1621
End page 1628
Total pages 8
Place of publication Cary, NC, United States
Publisher Oxford University Press
Collection year 2014
Language eng
Formatted abstract
Patients with inflammatory diseases are treated with a variety of biologic agents. The association between use of biologics and tuberculosis is well known. Additionally, there are numerous case reports of infections in patients receiving biologics with organisms such as Pneumocystis, Listeria, Legionella, and Salmonella. Data from the US Food and Drug Administration Adverse Event Reporting System suggest that infection with these organisms in patients receiving infliximab is at least 5 times as frequent as would be expected if there was no association between use of the drug and the infection. Each of these organisms is typically susceptible to trimethoprim-sulfamethoxazole (TMP-SMZ), and this therefore represents a potentially attractive prophylaxis to prevent these infections in patients receiving biologics. A randomized controlled trial of TMP-SMZ prophylaxis in patients receiving biologics is necessary to prove that its utility outweighs risk, but may be best preceded by a multisite case-control study to determine which patients receiving biologics are at greatest risk. 
Keyword Trimethoprim-sulfamethoxazole
Biologics
Prophylaxis
Infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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