Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes

Morihiro, Kunihiko, Kodama, Tetsuya, Kentefu, Moai, Yoshihiro, Veedu, Rakesh N. and Obika, Satoshi (2013) Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes. Angewandte Chemie-International Edition, 52 19: 5074-5078. doi:10.1002/anie.201300555


Author Morihiro, Kunihiko
Kodama, Tetsuya
Kentefu
Moai, Yoshihiro
Veedu, Rakesh N.
Obika, Satoshi
Title Selenomethylene locked nucleic acid enables reversible hybridization in response to redox changes
Journal name Angewandte Chemie-International Edition   Check publisher's open access policy
ISSN 1433-7851
1521-3773
Publication date 2013-01
Sub-type Article (original research)
DOI 10.1002/anie.201300555
Volume 52
Issue 19
Start page 5074
End page 5078
Total pages 5
Place of publication Weinheim, Germany
Publisher Wiley - V C H
Collection year 2014
Language eng
Abstract Locking up selenium: A new conformationally restricted nucleic acid with a 2′,4′-selenomethylene bridge (SeLNA) can be reversibly converted into its oxidized form (SeOLNA), and the hybridization of a modified oligonucleotide was shown to be dependent on the oxidation state. A SeLNA-modified molecular-beacon-type probe (see scheme; F=fluorophore, Q=quencher) can be used as a sensor for changes in the redox environment.
Keyword DNA hybridization
LNA
Nucleic acids
Redox chemistry
Selenium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
 
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