Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions

Ratheesh, Aparna, Priya, Rashmi and Yap, Alpha S. (2013). Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions. In Frans Van Roy (Ed.), Progress in molecular biology and translational science: the molecular biology of cadherins (pp. 49-68) London, United Kingdom: Academic Press (Elsevier). doi:10.1016/B978-0-12-394311-8.00003-0

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Author Ratheesh, Aparna
Priya, Rashmi
Yap, Alpha S.
Title of chapter Coordinating Rho and Rac: the regulation of Rho GTPase signaling and cadherin junctions
Title of book Progress in molecular biology and translational science: the molecular biology of cadherins
Place of Publication London, United Kingdom
Publisher Academic Press (Elsevier)
Publication Year 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/B978-0-12-394311-8.00003-0
Year available 2013
Series Progress in Molecular Biology and Translational Science
ISBN 9780123943118
ISSN 1877-1173
Editor Frans Van Roy
Volume number 116
Chapter number 3
Start page 49
End page 68
Total pages 20
Total chapters 19
Collection year 2014
Language eng
Abstract/Summary Cadherin-based cell-cell adhesions are dynamic structures that mediate tissue organization and morphogenesis. They link cells together, mediate cell-cell recognition, and influence cell shape, motility, proliferation, and differentiation. At the cellular level, moperation of classical cadherin adhesion systems is coordinated with cytoskeletal dynamics, contractility, and membrane trafficking to support productive interactions. Cadherin-based cell signaling is critical for the coordination of these many cellular processes. Here, we discuss the role of Rho family GTPases in cadherin signaling. We focus on understanding the pathways that utilize Rae and Rho in junctional biology, aiming to identify the mechanisms of upstream regulation and define how the effects of these activated GTPases might regulate the actin cytoskeleton to modulate the cellular processes involved in cadherin-based cell-cell interactions.
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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